BACKGROUND Long-term metoprolol therapy improves cardiac performance and decreases mortality in patients with chronic congestive heart failure (CHF). This study examined the effect of long-term metoprolol therapy on renal sodium handling in an experimental rat model of CHF. METHODS AND RESULTS Rats with left coronary ligation and myocardial infarction-induced CHF were treated with metoprolol ...

OBJECTIVE We investigated the effect of estrogen therapy on inflammatory responses, cardiovascular functions, and survival in a rat model of heatstroke. DESIGN Controlled, prospective study. SETTING Hospital medical research laboratory. SUBJECTS Sprague-Dawley rats (280-312 g of body weight, males and females). INTERVENTIONS Four major groups of anesthetized rats were designated for exp...

Individual vehicle information, especially, vehicle classification data play a key role in Advanced Traffic Management and Information Systems (ATMIS). In inductive loop and piezo-sensor fusion systems, traffic data such as the vehicle length and the distance between axles are used for vehicle classification. However, classification errors often occur in distinguishing passenger cars from small...

Bio-inspired vehicles are currently leading the way in the quest to produce a vehicle capable of flight and underwater navigation. However, a fully functional vehicle has not yet been realized. We present the first fully functional vehicle platform operating in air and underwater with seamless transition between both mediums. These unique capabilities combined with the hovering, high maneuverab...

PURPOSE To compare the efficacy of mapracorat (formerly ZK-245186, and subsequently BOL-303242-X), a novel selective glucocorticoid receptor agonist (SEGRA), with that of dexamethasone (DEX) in rabbit models of ocular disease. The effects of topical BOL-303242-X and DEX on intraocular pressure (IOP) and body weight changes were also evaluated. METHODS Dry eye was induced by atropine sulfate a...

testosterone enanthate (te) is used by many athletes as a muscle builder. previous studies showed that high concentration of the drug in plasma may affect the natural function of endocrine glands, specially the secretion of the adrenocortical hormones. the objective of the present study was to examine the effects of high concentration of te on histometrical structure of adrenal cortex in male r...

objective(s): brain edema is one of the most serious causes of death within the first few days after trauma brain injury (tbi). in this study we have investigated the role of shilajit on brain edema, blood-brain barrier (bbb) permeability, intracranial pressure (icp) and neurologic outcomes following brain trauma.   materials and methods: diffuse traumatic brain trauma was induced in rats by dr...

A hybrid micro air/ground vehicle has been developed and is specifically tailored to explore interior spaces with complex terrain. The vehicle, called the hopping rotochute, maneuvers through intricate environments by hopping over or through impeding obstacles. A small coaxial rotor system provides the necessary lift while a moveable internal mass allows directional control. In addition, the lo...

the aim of this manuscript is to study the implication of aluminium-oxide nanofluid for an amphibious vehicle engine (viable on land and under water) cooling system both analytically and experimentally. to achieve this, a one-dimensional model of the engine cooling system (radiator) is considered through a computational fluid code in which the mass flow rate for a range of the coolant temperatu...

Primary suspension is the term used for suspension components connecting the wheel assemblies of a vehicle to the frame of the vehicle (Fig.1). This is in contrast to the suspension components connecting the frame and body of the vehicle, or those components located directly at the vehicle’s seat, commonly called the secondary suspension. Usually a vehicle contains both primary and secondary su...