BACKGROUND AND PURPOSE A large percentage of patients with a cerebral arteriovenous malformation (AVM) show focal neurological signs or have a history of intracranial hemorrhage. The present study used transcranial Doppler sonography to assess the clinical significance of hemodynamic disturbances in the intracranial arteries of patients with an AVM. METHODS Eighteen patients with untreated AV...

Four experimental procedures were tried with the dog before one was found which enabled us to record vasomotor changes in an intracranial vascular bed, uncomplicated by alteration in vasomotor tone in the extracranial beds. This required extensive dissection and cannulation technics. In experiments in which this was accomplished by complete elimination, on one side, of the communications betwee...

The technic of total body perfusion with a pump oxygenator system has been used to extend pressure flow studies to the circulation as a whole. The effect of alterations in vasomotor tone on both total peripheral resistance and pressure flow relationships has been investigated by surgical ablation of the central nervous system or administration of vasoactive drugs. Certain aspects of the results...

Many epidemiologic studies include symptom checklists assessing recall of symptoms over a specified time period. Little research exists regarding the congruence of short-term symptom recall with daily self-reporting. The authors assessed the sensitivity and specificity of retrospective reporting of vasomotor symptoms using data from 567 participants in the Study of Women's Health Across the Nat...

OBJECTIVE The aim of this study was to demonstrate the ramifications of clinical variability of complex regional pain syndrome (CRPS) and how they can affect the various aspects of this condition, favorably or unfavorably, for both patients and participating medical and legal professionals. METHODS Twelve patients diagnosed with CRPS at different times in the past 25 years were followed up, a...

OBJECTIVE This report describes the Menopausal Strategies: Finding Lasting Answers to Symptoms and Health network and methodological issues addressed in designing and implementing vasomotor symptom trials. METHODS Established in response to a National Institutes of Health request for applications, the network was charged with conducting rapid throughput randomized trials of novel and understu...

BACKGROUND We demonstrated recently that the prevalence of neuronal (nNOS) over inducible (iNOS) nitric oxide synthase activity at the rostral ventrolateral medulla (RVLM), the medullary origin of sympathetic neurogenic vasomotor tone, and the associated dominance of sympathoexcitation over sympathoinhibition underlie the maintenance of sympathetic vasomotor outflow by the endogenous NO. Here, ...

Kisspeptin is a peptide expressed mainly in the infundibular nucleus of hypothalamus. plays crucial role regulation reproductive functions. It regarded as most important factor responsible for control hypothalamic–pituitary–gonadal axis, onset puberty, and menstruation fertility. activity influences numerous processes such steroidogenesis, follicular maturation, ovulation, ovarian senescence. T...

Treating Vasomotor Symptoms Although 85 percent of perimenopausal women have vasomotor symptoms (hot flushes), only one half of these women find them disturbing. Twenty percent of women will experience symptoms for less than one year, but approximately 50 percent of women may experience symptoms for five years or more. Conventional estrogen therapy is effective in controlling symptoms in more t...