The objective of the study was to analyze the frequency of APOE4 allele in elderly patients with Alzheimer’s or vascular dementia or depression; compare these to age/sex matched controls; compare the results with established literature and highlight new findings.A single center, multiple disease, case-control study was performed with three case groups- probable AD patients (n=36), vasc...

Dementia is a state of permanent loss of cognitive function, most commonly affecting the elderly. With a rapidly growing aged population, the spectrum of disorders that lead to dementia is exerting an ever-increasing toll on patients, families and society alike. The most common dementing disorders are Alzheimer’s disease and vascular dementia. Although Alzheimer’s disease is very common and was...

Dementia is a state of permanent loss of cognitive function, most commonly affecting the elderly. With a rapidly growing aged population, the spectrum of disorders that lead to dementia is exerting an ever-increasing toll on patients, families and society alike. The most common dementing disorders are Alzheimer’s disease and vascular dementia. Although Alzheimer’s disease is very common and was...

OBJECTIVES To study the association of apoE genotypes with dementia and cerebrovascular disorders in a population based sample of 85 year old people. METHODS A representative sample of 85 year old people (303 non-demented, 109 demented) were given a neuropsychiatric and a medical examination and head CT. The apoE isoforms were determined. Dementia was diagnosed according to DSM-III-R. RESUL...

The concept of vascular dementia is undergoing revision. The multi-infarct model and the Alzheimer's model of dementia, usually referred to as 'multi-infarct dementia', are gradually being replaced by a much broader concept of vascular cognitive impairment. This conceptual evolution reflects a more profound understanding of the pathogenic mechanisms that underlie this complex syndrome. As a con...

introduction: the aim of the global dementia scale factor structure roland (rudas) was conducted in patients with dementia. methods: this descriptive correlation study was conducted. population of all nursing home patients with dementia tehran bazaar was formed in 1390., in this study, 78 patients from the kahrizak nursing home patients with dementia sampling method selected data on the global ...

OBJECTIVES To provide the clinician with a guide to the clinical utility of 99mTc-HMPAO single photon emission computed tomography (SPECT) and to the interpretation of specific test results in the differential diagnosis of dementia. METHODS Three hundred and sixty three patients with dementia were studied prospectively for a median three (range 1-6) years and classified into disease groups on...

OBJECTIVE To investigate the efficacy and safety of Chinese herbal medicines in the treatment of patients with vascular dementia. DATA RETRIEVAL We retrieved publications from Cochrane Library (2004 to July 2011), PubMed (1966 to July 2011), the Chinese Science and Technique Journals Database (1977 to July 2011), the China National Knowledge Infrastructure (1979 to July 2011), Google Scholar ...

Background: Systemic and local inflammatory responses have been proposed as mechanisms in the initiation and progression of dementia. Several studies described increased levels of proinflammatory cytokines in Alzheimer's disease patients. Acute phase reactants such as CRP have been detected within the neuritic plaques and neurofibrillary tangles in the brains of patients with Alzheimer's diseas...