introduction compartmental analysis allows the mathematical separation of tissues and organs to determine activity concentration in each point of interest. biodistribution studies on humans are costly and complicated, whereas such assessments can be easily performed on rodents. in this study, we aimed to develop a pharmacokinetic model of 153sm-maltolate complex as a novel therapeutic agent and...

This research tends to development of the requirements elicitation methodology with regard to operational nature and hierarchical analysis for complex systems and also, regarding available technologies. This methodology applies Analytic Hierarchy Process (AHP) and Analytic Network Process (ANP) to ensure traceability of planned qualitative and quantitative data from requirements to available te...

The complexation reaction between salen (Bis(salicylidene)ethylenediamine) and Cu(II) cations in methanol (MeOH), 2-propanol (2-PrOH), acetonitrile (AN), tetrahydrofuran (THF), and chloroform (CHCl3) as nonaqueous solvents at 25º C has been investigated. The stoichiometry and formation constants of complexes have been determined spectrophotometrically and conductometrically by method of continu...

This research tends to development of the requirements elicitation methodology with regard to operational nature and hierarchical analysis for complex systems and also, regarding available technologies. This methodology applies Analytic Hierarchy Process (AHP) and Analytic Network Process (ANP) to ensure traceability of planned qualitative and quantitative data from requirements to available te...

In this work, a new spectrophotometric method for the determination of trace amount of Cobalt (ІІ) ionwas investigated and the stability constant of the related complex was evaluated 2.174 × 104. In the Cobalt(ІІ)-piroxicam complex, the maximum absorbance wavelength is 570 nm and the linearity of calibrationcurve was investigated (5-10 ppm). The relative standard deviation for seven replicate e...

Variation at regulatory elements, identified through hypersensitivity to digestion by DNase I, is believed to contribute to variation in complex traits, but the extent and consequences of this variation are poorly characterized. Analysis of terminally differentiated erythroblasts in eight inbred strains of mice identified reproducible variation at approximately 6% of DNase I hypersensitive site...

Introduction Compartmental analysis allows the mathematical separation of tissues and organs to determine activity concentration in each point of interest. Biodistribution studies on humans are costly and complicated, whereas such assessments can be easily performed on rodents. In this study, we aimed to develop a pharmacokinetic model of 153Sm-maltolate complex as a novel therapeutic agent and...