BACKGROUND Inadequacy of dialysis is one of the main causes of death in hemodialysis patients. Some studies have suggested that high-flux membrane improves the removal of moderate-sized molecules while other studies indicate no significant effect on them. OBJECTIVES This study aimed to investigate the dialysis efficacy of low-flux versus high-flux membranes in hemodialysis patients. PATIENT...

Integration of human papillomaviruses (HPVs) into the host genome is considered to be an early and important event in HPV-linked cervical carcinogenesis. Consequently, the viral DNA potentially becomes a target for cellular control mechanisms normally acting on the corresponding integration site. Besides resulting position effects, host-specific DNA methylation may play a functional role in HPV...

background and objectives: hemodialysis (hd) is one of the therapeutic modalities patients. since inadequate dialysis increases mortality and morbidity of patients, therefore, assessment of dialysis adequacy is clinically important. for this reason, hemodialysis adequacy was determined in patients undergoing maintenance hd at the mostafa khomeini hospital, tehran, iran. materials and methods: t...

When comparing the ability of two sequences to regulate the expression of a reporter gene, following transfection of cells in cultures, it is necessary to control for the potential difference in transfection efficiency. This is done by either conducting the experiment several times with at least two different preparations of each DNA or by adding a second plasmid (internal control plasmid) enco...

BACKGROUND The APOL1 gene variants has been shown to be associated with an increased risk of multiple kinds of diseases, particularly in African Americans, but not in Caucasians and Asians. In this study, we explored the single nucleotide polymorphism (SNP) and haplotype diversity of APOL1 gene in different races provided by 1000 Genomes project. METHODS Variants of APOL1 gene in 1000 Genome ...