I Is fitting that the inaugural issue of the Journal ofthe American Society ofNephrology highlights the 1990 Long Range Plan of the National Kidney and Urologic Diseases Advisory Board. The release of this historic report in March 1 990 signalled the beginning of a critical period for the future of nephrology. Achievement of the major recommendations outlined In this long-range plan would subst...

Early diagnosis and surveillance for metastasis and recurrences are critical issues of urologic cancer. Deregulation of long non-coding RNAs (lncRNAs) has been implicated in urologic malignancies and represents potential markers or therapeutic targets. However, the utility of lncRNA as biomarkers appears to be overstated due to heterogeneous or irreproducible results from different studies. Thu...

Urologic complications associated with the ureterovesical anastomosis after transplantation may cause graft loss and mortality [1]. Today, extravesical ureteroneocystostomy has become a popular procedure to reestablish urinary tract continuity in renal transplantation. Complication rates vary from around 20% to less than 5% [2, 3]. At many transplantation centers, surgeons have adopted new sutu...

Urologists may be concerned that treatment of patients with interstitial cystitis (IC) is not economically feasible, and the time spent on these patients could be used for more profitable urologic therapy. However, care of IC patients can provide urologic practices with increased revenue opportunities through a wide range of procedures, including IC evaluation and management, treatment planning...

The American Cancer Society has estimated that in 2003, there will be approximately 239,600 new cases of urologic cancer diagnosed and 54,600 urologic cancer-related deaths in the United States. To date, the majority of research and therapy design have focused on the microenvironment of the primary tumor site, as well as the microenvironment of the metastatic or secondary (target) tumor site. L...

Coordination of care between the urologist and primary care physician is critical to effective treatment of a variety of urologic conditions. Medical therapies for benign prostatic hyperplasia, erectile dysfunction, hypogonadism, overactive bladder, and prostate cancer are widely available and a basic understanding of the pathophysiology of these disease states as well as the pharmacology of ex...

Asymptomatic microscopic hematuria is a common finding that demands urologic evaluation. Of the 236 patients over the age of 40, 6.8% were found to have a genitourinary cancer, while 27.5% had other significant urologic disease. However, 52.1% of the patients had unknown etiology of microscopic hematuria and 13.6% had insignificant urologic lesions. Of the 72 patients under the age of 40 a posi...