Background & Aims: Hydronephrosis is a common problem in prenatal and newborn infants diagnosed by ultrasonography. Bladder to ureter reflux, the upper or lower urinary tract obstruction, and neurogenic bladder are the most common causes of hydronephrosis in newborns and infants. Methods: In this study, 100 neonates and infants with hydronephrosis were observed clinically and laboratorically fo...

Benign prostatic hyperplasia (BPH) is a common condition affecting over 50% of men as they reach the 5th decade of their life [1]. While over half of these patients have symptoms, it is not clear why some of these men do while others do not. The article Solving the benign prostatic hyperplasia puzzle by Keong Tatt Foo [2], delves into the different conundrums urologists face when trying to trea...

megacystis microcolon intestinal hypoperistalsis syndrome (mmihs) is a rare and the most severe form of functional intestinal obstruction in the newborn. the characteristic features of this congenital and fatal disease are abdominal distension, absent or decreased bowel peristalsis. abdominal distension is a consequence of the distended, unobstructed urinary bladder with or without hydronephros...

PURPOSE Antagonists of alpha 1-adrenergic receptors (alpha 1ARs) relieve obstructive and irritative symptoms in patients with bladder outlet obstruction. However, to our knowledge mechanisms underlying the relief of irritative symptoms remain unknown. Because bladder alpha 1dARs are up-regulated in some rats with bladder outlet obstruction, we investigated the effect of the alpha 1aAR antagonis...

Background:Spontaneous bladder rupture is a rare condition, and almost all the reported cases in the world have been preceded by bladder dysfunction, radiotherapy, urinary tract obstruction, pelvic surgery, inflammation, and malignancy. Case report: In this study, we present the case of a 39-year-old woman (G: 4, P: 1, Ab: 2) who was in week 38 of pregnancy and attended our hospital with the on...

The urinary bladder stones are formed due to urinary retention, obstruction to the flow of urine commonly caused by enlargement of the prostate in males, urinary tract infections, and foreign body. The urinary bladder stones are usually found in males, and its presentation in females is a rare entity. Recurrence of urinary tract stones is commonly due to either repeated urinary tract infections...

Bladder calculi in adults are common and occur as a result of bladder outlet obstruction. Though most of them are composed of calcium, in a few cases the stones may be composed of uric acid.We report on a 72 year old male who presented himself for a health check-up and incidentally was diagnosed to have multiple bladder calculi (85), the largest being 25 mm. Despite the large stone burden, the ...

PURPOSE We investigated the effects of mirodenafil, a phosphodiesterase-5 inhibitor developed in South Korea, on the female rat bladder in a partial bladder outlet obstruction (BOO) model. MATERIALS AND METHODS Thirty-six female Sprague-Dawley rats were divided into four groups: the control group, BOO without medication group, BOO with mirodenafil 1 mg/kg group, and BOO with mirodenafil 4 mg/...

The discovery of microRNAs (miRNAs), which are ~22 nucleotide RNAs that inhibit protein synthesis in a sequence-specific manner and are present in a range of species, has born hope of new therapeutic strategies. miRNAs play important roles in development and disease, but they remain poorly studied in uropathologies beyond cancer. Here, we discuss biological functions of miRNAs in the lower urog...

OBJECTIVES To describe the urodynamic characteristics of men with urinary retention, and to show the diverse treatment plans based on urodynamic findings. METHODS We carried out a 3-year retrospective review of men with urinary retention who were referred to our clinic for urodynamic evaluation. Men with a history of neurogenic voiding dysfunction or major pelvic surgery were excluded. Multic...