The potency of a series of Hexamethylene bis-acetamide (HMBA) derivatives inducing Hexamethylene bis-acetamide inducible protein 1 (HEXIM1) was determined in LNCaP prostate cancer cells. Several compounds with unsymmetrical structures showed significantly improved activity. Distinct from HMBA, these analogs have increased hydrophobicity and can improve the short half-life of HMBA, which is one ...

Starting from anilines and anhydrides a range of aminooxo-acids were prepared with excellent yields reaction times using an acyltransferase M. smegmatis (MsAcT) in water. Applying this process key intermediate SAHA was synthesized.

One of the major problems in direct power-controlled grid-connected voltage source converters is that during dips, converter current increases to compensate for reduced grid voltage. The most common dips are unsymmetrical, and they cause unbalance distortion current. This paper introduces a new, simple but effective algorithm which limits dips. A positive-sequence virtual-flux based control sch...

We prepared a significant number of unsymmetrical liquid-crystalline dimers that exhibit the twist-bend nematic phase; a state of matter that exhibits spontaneous breaking of mirror symmetry and, for some materials, a microsecond electrooptic response. A number of novel unsymmetrical bimesogens were synthesized and in comparing their thermal behaviour to previous literature examples, we have un...

Bagasse acetate butyrates were prepared homogeneously in 1-butyl-3methylimidazolium chloride ([C4mim]Cl) ionic liquid from ball-milled sugarcane bagasse by acylation with acetic anhydride and butyric anhydride. The parameters, including reaction temperature, reaction time, feeding method of adding anhydrides, the dosage of total anhydrides to SCB, and the molar ratio of acetic anhydride to buty...

The alternating copolymerization of epoxides and cyclic anhydrides is an increasingly popular route to aliphatic polyesters that are of interest as biodegradable replacements for petroleum-based polymers and for use in the biomedical field. However, broad and bimodal molecular weight distributions in these polymerizations continues to be an issue, limiting synthesis of multiblock copolymers. By...

This paper starts with developing kinematic and dynamic model of a snake shape robot in serpentine locomotion and finishes with actual experimentation. At the beginning the symmetrical and unsymmetrical serpenoid curves are introduced. Kinematics and dynamics of a snake robot on flat and inclined surfaces are obtained for a general n-link robot. SimMechanics toolbox of MATLAB software is employ...

Biodegradable polymers are a promising sustainable alternative to conventional petroleum-based and have attracted recent extensive research interest due their potential environmental friendliness sustainability. Among them, aliphatic polyesters polycarbonates the most extensively studied ones. The metal-catalyzed ring-opening polymerization (ROP) of cyclic esters copolymerization (ROCOP) epoxid...

Experimental and theoretical rationalization on regioselective mixed diboration of alkenes, with the unsymmetrical diboron reagent Bpin-Bdan, providing the protecting Bdan moiety in the internal position.