Abstract Study question: What is the optimal work-up to establish diagnosis of unexplained infertility, based on best available evidence in literature? Summary answer: The ESHRE Guideline Unexplained Infertility provides 35 recommendations infertility. known already? infertility made when no abnormalities female and/or male reproductive systems are clearly identified. UI inevitably a by exclusi...

INTRODUCTION Male infertility factor is defined if the total number of motile spermatozoa (TMSC) < 20 × 10(6)/ejaculated, and unexplained infertility if spermiogram is normal with normal female factor. THE AIM of this study was to determine the predictive value of TMSC for spontaneous pregnancy (ST) and pregnancy after treatment with intrauterine insemination (IUI) in couples with male factor...

Stimulated intrauterine insemination (IUI) should be the first choice treatment for mild male factor infertility, unexplained infertility or minimal to mild endometriosis. In mild male factor infertility, unexplained infertility, IUI is as effective as IVF & at 1/3 of the cost per pregnancy. In couples with the most severe semen defects, IUI in natural cycle should be the treatment of choice. I...

background: meiotic genes are very important candidates for genes contributing to female and male infertility. mammalian mutl homologues have dual roles in dna mismatch repair (mmr) after replication errors and meiotic reciprocal recombination. the mutl homologs, mlh1 and mlh3 , are crucial for meiotic reciprocal recombination and human fertility. in this study the functional polymorphisms of m...