With a modification of the Jerne plaque technique to enumerate plaque-forming cells (PFC) to bovine and rabbit thyroglobulin, the cellular kinetics of the antibody response were followed during two 5-day series of injections of an aqueous preparation of bovine thyroglobulin. The results support the suggestion that thyroiditis in the rabbit is mediated by antibody. The peak PFC appear in the spl...

Several studies have appeared in the past 25 years (l-5) concerning the physicochemical properties of thyroglobulin, the protein precursor of the thyroid hormone thyroxine. Most of this work has utilized hog thyroid gland as a source of material. The various investigations are in rather good agreement in obtaining a molecular weight for thyroglobulin close to -$ million. Moreover, this form of ...

Gostimir MIKAČ Faculty of Medicine Save Mrkalja 22 78000 Banja Luka Republic of Srpska Bosnia and Herzegovina [email protected] SUMMARY Introduction Thyroglobulin is composed glycoprotein, and it is synthesized by follicular cells of the thyroid gland. Treatment of differentiated thyroid carcinomas involves total thyroidectomy followed by radioiodine ablation of a potential remaining tissue. The m...

The dependent tumors exhibited minor chromosomal changes and thyroglobulin antigenicity similar to that of normal rat thyroid. The transitional tumors exhibited moderate chromosomal alterations and practically no thyroglobulin antigenicity. The autonomous tumors exhibited severe chromosomal alteration, numerically and/or structurally, and no detectable immunogenicity related to thyroglobulin. A...

Background: Serum thyroglobulin appears to be a sensitive marker of thyroid dysfunction in endemic goiter. However, its value as an indicator of thyroid status in children after the introduction of iodized salt has not been tested. Objective: The objective was to optimize and validate a thyroglobulin assay on dried whole blood spots and to evaluate thyroglobulin as an indicator of thyroid respo...

BACKGROUND AND PURPOSE Washout thyroglobulin provides evidence for metastatic or recurrent lesions, However, the cutoff value is still controversial. We investigated an optimized cutoff value and indication for the use of washout thyroglobulin from fine-needle aspiration in neck lymph nodes from preoperative or postoperative patients with well-differentiated thyroid cancers. MATERIALS AND MET...

Thyroid tissue obtained from 12 patients with Graves' disease and treated with thionamide drugs for 3-7 mo before subtotal thyroidectomy, from 12 patients with Graves' disease, similarly treated, and given 50 mug of triiodothyronine (T3) for 10 days before surgery, and from 12 euthyroid patients with solitary cold nodules was investigated to compare in vitro iodination of thyroglobulin in toxic...

Tyrosine kinase inhibitors (TKIs) are molecular targeted therapies used in the treatment of various malignancies. Thyroid dysfunction is an increasingly recognized adverse effect TKIs. We report a case TKI-associated thyroid patient with advanced lung cancer. A 61-year-old woman, Eastern Cooperative Oncology Group (ECOG) performance status 0, presented 5-month history cough. CT scan demonstrate...

Previous work (Herscovics, 1969) demonstrated that mannose and galactose are incorporated into the carbohydrate groups of thyroglobulin at different times in the elaboration of this glycoprotein from its subunit precursors. Mannose is incorporated on subunits of thyroglobulin at about the time of their synthesis, whereas galactose is incorporated over 30min later near the time of aggregation of...