The high rate of glycolysis in cancerous tissues, first described by Con in vivo (6) and by Warburg in vitro (@2),suggests that a considerable part of the energy supply for the neoplastic process is derived from the “anaerobic―phase of carbo hydrate catabolism. The low glycogen content characterizing a number of tumors (8—11, 13, I 7) may also indicate that the substrate for this process ...

5-AminolevuHnate (ALA) photodynamic therapy (PDT) is being used clinically for the treatment of skin cancers. ALA is applied as a precursor of porphyrins serving as endogenous photosensitizers. Irradiation of HaCaT cells preincubated with 1 HIMALA for 24 h with red light of 570-750 nm at a dose of 4.5 .I/cm' leads to a 6-fold elevation of cellular c-Jun N-terminal kinase activity; phosphorylati...

The highly mutagenic heterocyclic amines, 2-amino-3-methylimidazo[4,5-nquinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MelQ), are formed during heating of pro tein-rich foods. In order to gain information about the distribution and fate of IQ and MelQ in vivo, a whole-body autoradiographic study of i.v.-injected 14C-labeled IQ and MelQ has been per formed in male NMRI, pregnant ...

NB/70K, a tumor-associated antigen of human ovarian epi thelial tumor Fraction OCA, has been purified and identified as a glycoprotein which is stable in 0.6 M perchloric acid, binds to concanavalin A, and migrates electrophoretically with a-like mobility in barbital-buffered agarose at pH 8.6. NB/70K does not appear to contain normal serum, normal ovary, normal lung, or carcinoembryonic antige...

DL-GIyceraldehyde, a known inhibitor of glycolysis which does not appreciably af fect respiration, has been found to depress the incorporation of labeled leucine into pro tein of normal and neoplastic tissues, in vitro. With Yoshida ascites hepatoma cells, the inhibition of amino acid incorporation into protein occurred both in aerobic and anaerobic conditions, the L-isomer being apparently mor...

Pyruvate kinase M2 (PKM2) has been studied for decades on its role in cancer metabolism. Re-cently, PKM2 is highlighted again for its new function: promoting gene transcription by acting as a pro-tein kinase. Moreover, the PKM2 levels in patient circulation have been used as a diagnostic marker formany types of cancers. However, it remains unclear whether PKM2 in blood circulati...

We have recently demonstrated that certain camptothecin derivatives are effective agents in the treatment of human tumor xenografts in nude mice. \Yhile camptothecin and its derivatives are recognized as inhibitors of topoisomerase I, little is known about the effects of these agents on specific gene expression, particularly genes involved in growth control. The c-jun early response gene codes ...

Abstract This article theorizes the modernization dynamics of Igbo world, using Habermasian framework. Drawing on Habermas, it argues that modernity or, more precisely, transformations associated with modernization, may be understood in terms “uncoupling” systems from lifeworld. Relatedly, further crises and pathologies attend Igboland owe largely to “colonization” lifeworld by consequent upon ...

The products of PI 3-kinase activation, PtdIns(3,4,5)P3 and its immediate breakdown product PtdIns(3,4)P2, trigger physiological processes, by interacting with proteins possessing pleckstrin homology (PH) domains. One of the best characterized PtdIns(3,4,5)P3/PtdIns(3,4)P2 effector proteins is protein kinase B (PKB), also known as Akt. PKB possesses a PH domain located at its N terminus, and th...