OBJECTIVE Peptic ulcer perforation continues to be a major surgical problem. In this study, risk factors that influence morbidity and mortality in perforated peptic ulcer disease were examined. MATERIAL AND METHODS Files of 148 patients who were included in the study due to peptic ulcer perforation between January 2006 and December 2010 were retrospectively analyzed. Data regarding age, gende...

Various studies have indicated that peptic ulcers occurring during the course of diabetic state are more severe and often associated with complications such as gastrointestinal bleeding. This study is an attempt to understand the pathogenesis of indomethacin-induced gastric ulcers occurring during the diabetic state using suitable markers and its amelioration by quercetin and coenzyme Q10 (CoQ1...

Nineteen healthy subjects were studied and 17 patients with gastric ulcer before and after ulcer healing with carbenoxolone. Gastric deoxytibonucleic acid (DNA) loss was measured as an index of epithelial cell turnover, and N-acetylneuraminic acid (NANA) content of gastric juice as an index of mucus secretion. In normal subjects there was a negative correlation (p less that 0-025) between gastr...

Diabetes mellitus is a widely spread chronic disease with growing incidence worldwide, and diabetic foot ulcer is one of the most serious complications of diabetes. Cellular therapy has shown promise in the management of diabetic foot ulcer in many preclinical experiments and clinical researches. Here, we performed a meta-analysis to evaluate the efficacy and safety of cellular therapy in the m...

the   stembark of mammea africana is used traditionally for the treatment of stomach pains. the present study was designed to evaluate the effects of ethanolic stembark extract of mammea africana on experimentally induced diarrhoea and ulcer . the extract ( 30 – 90mg/kg) was administered orally in rats 30 minutes to one hour before the induction of diarrhoeal and ulcer using different experimen...

The anti-ulcer activity of Methanolic extract Myrica nagi (Myricaceae) fruit MEMN was investigated in pylorus ligation and methanol-induced ulcer models Wistar rats. In both models, the common parameter determined index at doses 200,400 mg/kg p.o produced significant inhibition gastric lesions induced by Aspirin-induced ulcers & ligation-induced ulcers. (200, 400 mg/kg) showed a (P < 0.0...

This study investigated the gastroprotective effect of Lcarnitine against indomethacin-induced gastric ulcer in rats and the possible mechanisms underlying this effect. Two sets of experiments were performed. In the first set male albino rats (170-210 g) were randomly allocated into a normal control group, ulcer control group (received a single dose of indomethacin 30 mg/kg po) and three ulcer ...

BACKGROUND Low socioeconomical status is a major risk factor for natural acquisition of Helicobacter pylori (H. pylori) infection in developing countries. Its transmission route is unknown but studies suggest person-to-person transmission. AIM To evaluate seropositivity of anti-H. pylori antibodies in family members of infected symptomatic index patients as compared to family members of sympt...

Glycyrrhiza glabra L. is used in folk medicine for treatment of stomach disorders including peptic ulcers. The hydroalcoholic extract of Glycyrrhiza glabra L. (HEGG) was evaluated for antiulcerogenic activity and acute toxicity profile in mice. Various doses of HEGG (50-200 mg/kg) were administered orally to animals of different groups. Omeprazole and cimetidine at doses of 30 and 100 mg/kg wer...