Abstract. A popular modeling technique in mortgage banking involves regarding mortgage terminations observed in a continuously replenished system (such as a servicing portfolio) as a Markov process of …nite order k > 0 with values in a …nite state space. In this article, we consider the rami…cations of such an assumption. In particular,we conduct hypothesis tests of long-range dependence on a w...

Seventy-seven microorganisms were examined for their ability to metabolize the antineoplastic agent N-methylcolchiceinamide, an analog of colchicine. Five streptomycetes exhibited significant metabolism, and Streptomyces griseus NRRL B-599 completely converted the substrate to three metabolites. In preparative-scale studies, N-dealkylation resulted in the production of colchiceinamide, the majo...

1 Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK 2 Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK 3 Division of Psychiatry, University of Edinburgh, Edinburgh, EH10 5HF, UK 4 Medical Genetics Section, University of Edinburgh Centre for Genomics and Experimental Medicine and MRC I...

The built environment (BE) has emerged as one of the 'first causes' of chronic disease, capable of explaining its socio-spatial variation. There is an increasing need spatial modelling for objective, detailed and precise measurements of attributes of BE that may influence our lifestyle, behaviour and hence physical and mental health. The talk will report the UK Biobank Urban Morphometric Platfo...

We examined the association between Neuroticism and mortality in 321 456 people from UK Biobank and explored the influence of self-rated health on this relationship. After ageand sexadjustment, a standard deviation increment in Neuroticism was associated with a 6% increase in all-cause mortality (hazard ratio = 1.06, 95% confidence interval = [1.03, 1.09]). After adjustment for other covariates...

its membership – one of them contributed to the withdrawal of the arthritis drug Vioxx. With this track record, and the option to bank on some degree of community spirit among its membership, Kaiser Permanente may find it easier to gain the trust of the target population than the UK Biobank did. They also may want to find a different name for the project, for who would trust a bank these days? ...

A heterogeneous target disease represented by multiple descriptors and disease subtypes frequently has a rich internal dependency structure. The identification of comorbidities and particularly the multimorbidities of such diseases requires very large sample size as relevant comorbidities may form complex interactions. We demonstrate this phenomena by applying a Bayesian probabilistic graphical...

Konusma tanima, soylenen kelime ve cumlelerin metne donusturulmesidir. Son zamanlarda bircok ulkede konusma tanima ile ilgili calisma yapilmistir, fakat ulkemizde uygulamalari yapilan calismalar cok azdir, bunun nedenlerinden biri ses veri seti eksikligidir. Bu calismada, Turkce tabanli sistemler icin bir tabani gelistirilmistir. Ses kayitlari haber tv kanallarinin farkli yayinladiklari haberle...