Ugi reactions have been widely studied due to their mild reaction conditions, high structural variability, and wide applications. adducts proved be highly efficient for different kinds of post-transformations by carefully choosing the starting four components. Considering importance polycycles, diverse post-Ugi transformations employed construction structurally novel polycyclic N-heterocycles. ...

QUESTIONS UNDER STUDY/PRINCIPLES In most centers, Upper Gastrointestinal series (UGI) following Roux-en-Y Gastric Bypass (RYGB) is performed to rule out GJ anastomotic leak. According to the introduction of robotic technology associated with a hypothetical decrease of anastomotic complications, we aim to assess the validity and cost effectiveness of early routine UGI following robot-assisted RY...

OBJECTIVE To analyse serious upper gastrointestinal (UGI) complications associated with non-salicylate non-steroidal anti-inflammatory drugs (NSAIDs) in children. METHODS All serious UGI complications associated with non-salicylate NSAIDs approved in France to treat moderate pain or fever in children, spontaneously reported to the French Pharmacovigilance system or to the companies, between t...

Phenothiazinyl and carbazolyl-donor moieties can be covalently coupled to an anthraquinone acceptor unit through an Ugi four-component reaction in a rapid, highly convergent fashion and with moderate to good yields. These novel donor-acceptor dyads are electronically decoupled in the electronic ground state according to UV-vis spectroscopy and cyclic voltammetry. However, in the excited state t...

For the first time, spin-labelled coumpounds have been obtained by isonitrile-based multi component reactions (IMCRs). The typical IMCR Ugi-protocols offer a simple experimental setup allowing structural variety by which labelled diketopiperazines (DKPs) and peptide-peptoid chimera have been synthesized. The reaction keeps the paramagnetic spin label intact and offers a simple and versatile rou...

In the context of high-quality urban development and increasingly important role green infrastructure (UGI) in public life, landscape activity (LA) has gradually become a dominant indicator for improving UGI quality efficiency, as well optimizing its environmental friendliness meeting recreational needs public. Relevant studies have shown that ecological index (EI) vitality (PVI) can characteri...

OBJECTIVES Upper gastrointestinal (UGI) bleeding carries high morbidity and mortality. The use of a bleeding care pathway (BCP) may improve outcomes, but the results are inconsistent in various studies. METHODS A BCP for patients with UGI bleed with admission in a bleeding care unit (BCU) has been in use at our hospital since 2005. Prior to this, a high dependency unit was used for management...

BACKGROUND Gastro-protective agents (GPA) are co-prescribed with non-steroidal anti-inflammatory drugs (NSAID) to lower the risk of upper gastrointestinal (UGI) events. It is unknown to what extent the protective effect is influenced by therapy adherence. AIM To study the association between GPA adherence and UGI events among non-selective (ns) NSAID users. METHODS The General Practice Rese...