نتایج جستجو برای: type vii collagen
تعداد نتایج: 1402056 فیلتر نتایج به سال:
Recessive dystrophic epidermolysis bullosa (RDEB) is a genodermatosis characterized by fragile skin forming blisters that heal invariably with scars. It is due to mutations in the COL7A1 gene encoding type VII collagen, the major component of anchoring fibrils connecting the cutaneous basement membrane to the dermis. Identical COL7A1 mutations often result in inter- and intra-familial disease v...
Genetic loss of collagen VII causes recessive dystrophic epidermolysis bullosa (RDEB), a skin fragility disorder that, unexpectedly, manifests also with elevated colonization of commensal bacteria and frequent wound infections. Here, we describe an unprecedented systemic function of collagen VII as a member of a unique innate immune-supporting multiprotein complex in spleen and lymph nodes. In ...
The healthy-looking non-lesional (NL) psoriatic skin already carries some alterations. These alterations include extracellular matrix defects such as the disruption of laminin networks, which may lead to impaired keratinocyte adhesion basal membrane. This process is associated with aberrant expression α5β1 integrin complex and extradomain-A-containing fibronectin (EDA+FN) around keratinocytes. ...
BACKGROUND In allergic asthma, IgE increases airway remodelling but the mechanism is incompletely understood. Airway remodelling consists of two independent events increased cell numbers and enhanced extracellular matrix deposition, and the mechanism by which IgE up-regulates cell proliferation and extracellular matrix deposition by human airway smooth muscle cells in asthma is unclear. OBJEC...
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