TWIST, a basic helix-loop-helix (bHLH) transcription factor that regulates mesodermal development, has been shown to promote tumor cell metastasis and to enhance survival in response to cytotoxic stress. Our analysis of rat C6 glioma cell-derived cDNA revealed TWIST expression, suggesting that the gene may play a role in the genesis and physiology of primary brain tumors. To further delineate a...

The objective of this paper is to investigate the viscous shear heating effect on the formation of minimum film thickness in inlet zone of the hydrostatic extrusion process as function of various operating parameters. Minimum film thicknesses in the inlet zone has been evaluated at various extrusion speeds, material parameters, extrusion pressures, and die semiangle for extrusion of low strengt...

This paper presents a new interpretation of the binary blending operator of implicit modeling. Instead of considering the operator as a composition of potential functions, we propose to consider it as an implicit curve extruded in an implicit extrusion field. An implicit extrusion field is a 2D space for which each coordinate is a potential field. The study of general concepts around implicit e...

Altered expression of Twist, matrix metalloproteinase (MMP)-2 and MMP-9 proteins has been identified in various types of human cancers. However, the correlation between Twist and these gelatinases in breast cancer remains unclear. In this study, immunohistochemical analysis of Twist, MMP-2 and MMP-9 expression was performed on tissue microarrays from 200 breast cancer cases. The association of ...

PURPOSE This study aimed to explore the role of the Twist gene in the epithelial-mesenchymal transition of ovarian cancer. METHODS An RNA interference plasmid expressing a small interfering RNA (siRNA)-targeting Twist (Twist siRNA vector) was designed, constructed, and transfected into the human ovarian cancer cell line A2780. Transfection efficiency was assessed under a fluorescence microsco...

Twist, a key regulator of epithelial-mesenchymal transition (EMT), plays an important role in the development of a tumorigenic phenotype. Energy metabolism reprogramming (EMR), a newly discovered hallmark of cancer cells, potentiates cancer cell proliferation, survival, and invasion. Currently little is known about the effects of Twist on tumor EMR. In this study, we found that glucose consumpt...

In the present study the effect of phase volume fraction on the reinforcement of microstructure and tensile properties of composite extrusion process Al6061/SiC has been studied. For this purpose, the base alloy Al6061 using pure aluminum ingots, silicon, of Al-50% Mg, Al-10% Cr and a thin copper rod was prepared. Next, the composite Al6061/5% SiC, Al6061/10% SiC, Al6061/15% SiC and Al6061/20% ...

Low-temperature incipient melting and high deformation resistance of aluminium alloy AA7075 place extraordinary demands on extrusion die design and process optimization, especially when the shape of the extrudate is complex. The present case study was aimed at combining the considerations on die design and process optimization for the alloy to manufacture a complex solid profile with large diff...