Methamphetamine (Meth) is recognized as one of the most important new distributedabused drug that causes severe damage to the different parts of the brain, especiallyhippocampus. Previous studies have demonstrated that Meth can induce apoptosis and celldeath in the brain. In this study, we evaluated the long-term effects of Meth abuse in theCA1 region of postmortem hippo...

  Background and Objective: Garlic has been known worldwide as a dietary constituent with many pharmacological effects. The present in vitro study was designed to investigate the putative anticancer effect of garlic extract on cancer cells, and if this effect was through apoptosis induction. Material and Methods:  Human colon adenocarcinoma cells HT29 were treated with different doses (1, 5 a...

Wilms tumor (WT) is the most common pediatric malignant primary renal tumor. Carboplatin (CRB), a platinum compound is widely used in the treatment of multiple cancers including ovarian, lung, head and neck, and wilm’s tumor. However lower uptake of CRB in cancer cells and toxicity concerns in healthy cells often limited its clinical outcome. The aim of this study was to investigate the antitum...

Background: Endometriosis is a benign hormone-dependent disease in women of reproductive age. There is no cure for eradicating the disease and there is need for new drugs. The aim of this study was to investigate the in vitro effect of noscapine as inducer of cell death on endometriotic stromal cells in patient's endometriosis in vitro. Materials and Methods: Endometrial biopsies from pati...

BACKGROUND Glioma is still one of the most complicated forms of brain tumor to remove completely due to its location and the lack of an efficient means to specifically eliminate tumor cells. For these reasons, this study has examined the effectiveness of a nonviral gene therapy approach utilizing a tumor-selective killer gene on a brain tumor xenograft model. METHODS AND RESULTS The therapeut...

Polydatin, a small molecule from Polygonum cuspidatum, has many biological functions, particularly anti-cancer effects. However, the anti-cancer effects of polydatin in hepatocellular carcinoma (HCC) have not been examined yet. In the present study, MTT assay, BrdU assay, transwell invasion assay, and wound healing assay were performed to determine cell proliferation, invasion and migration. Fl...

Purpose: To investigate the role of embelin in periodontal ligament stem cells (PDLSCs) an vitro model periodontitis.Methods: Lipopolysaccharide (LPS)-stimulated PDLSCs was used to construct a periodontitis cell model. treatment group were pretreated with different concentrations Embelin, and CCK-8 TUNEL staining analyze viability apoptosis. Enzyme-linked immunosorbent assay (ELISA) kits evalua...

Purpose: To investigate the therapeutic role of diosmetin in periodontitis and its probable mechanism action.Methods: Lipopolysaccharide (LPS) was used to induce periodontal cells. Cell viability apoptosis response LPS were evaluated using MTT TUNEL assays. The oxidative stress inflammatory responses LPS-induced effects cells detected enzyme-linked immunosorbent assay (ELISA). In addition, role...