conclusion: in this study group, tnf-α -238 polymorphism was shown to be different in preeclamptic and non-preeclamptic pregnant women. the aa genotype and the a allele may carry an increased risk for developing of preeclampsia. results: there were significant differences between the two groups in tnf-α genotype at position -238 (p < 0.001). in the preeclamptic group, the frequency of the aa ge...

background: despite the emerging evidence on beneficial effects of probiotics on the cardiovascular system, their impact on the management of ischemic heart diseases and its possible mechanism have not been elucidated. methods: four viable probiotics bacterial strains, including bifidobacterium breve, lactobacillus casei, lactobacillus bulgaricus and lactobacillus acidophilus, at the concentrat...

background:  levels of anti-inflammatory cytokines in blood have a positive relationship with congenital heart disease (chd). we sought to assess the difference in serum cytokines levels between children with and without chd.  methods:  we recruited 60 patients with chd and 30 healthy children, from 2013 to 2014. patients with primary pulmonary hypertension; metabolic diseases; renal, endocrine...

background: probiotics are microorganisms that may influence brain function via altering brain neurochemistry. new research evidence suggests that probiotic bacteria might protect tissue damage through diminishing the production of free radicals and/or inflammatory cytokines. therefore, this study was designed to evaluate the effects of probiotic bacteria on the prevention or reduction of brain...

Tumor necrosis factor-alpha (TNF-α) is a cytokine that plays an important role in inflammatory process and tumor development. Recent studies demonstrate that triterpene saponins from Vietnamese ginseng are efficient inhibitors of TNF-α. But the interactions between TNF-α and the saponins are still unclear. In this study, molecular docking and molecular dynamics simulations of TNF-α with three d...

Background: Nanomedicine has emerged as a powerful platform for applying nanotechnology in the prevention and treating many diseases. Objective: To investigate toxicity of designated anti-cancer drugs composed gold nanoparticles (GNPs), tumor necrosis factor-alpha (TNF-α), cysteine-Alanine-Leucine-Asparagine-Asparagine (CALNN) peptide on kidney liver parameters, using animals’ model. Methods: A...

ABSTRAK Pendahuluan: Periodontitis Apikalis (PA) adalah peradangan jaringan periapikal yang berawal dari lesi karies. Tubuli dentin terbuka akibat adanya karies menjadi jalan masuk bakteri dan produknya. Proses ini akan terus berlanjut hingga mengakibatkan nekrosis pulpa berat sampai ke gigi. Infeksi pada gigi memediasi menginduksi sel untuk mengeluarkan sitokin proinflamasi. Tumor Necrosis Fac...

Triple Negative Breast Cancer (TNBC) immunotherapy has recently shown promising approach. However, some TNBC patients presented with resistance. One of the reasons was attributed to excessive release cytokines at tumor microenvironment (TME) such as Tumor necrosis factor alpha (TNF-α) and Interleukin-10 (IL-10). Fine regulation these cytokines’ levels via non-coding RNAs (ncRNAs) might alleviat...

Tumor necrosis factor alpha (TNF, TNFSF2) is an important multifunctional cytokine that regulates inflammation, host defense, immune responses, and apoptosis. TNF exists as a membrane-bound 26kDa, type II integral membrane protein, and a 17kDa soluble homotrimeric TNF that is generated via proteolytic cleavage by TNF-a converting enzyme (TACE, ADAM17). Both the membrane-bound and soluble forms ...