Introduction: Magnetic nanoparticle (MNP) hyperthermia is a promising cancer treatment approach. It is based on the evidence that by injecting MNPs such as Fe3O4 in the tumor and subjecting them to an alternating magnetic field, they release heat, generating temperatures up to 42°C that can kill cancer cells by apoptosis, usually with lowest damage to normal tissue. In previous...

Re-irradiation is challenging for esophageal cancer patients with local-regional recurrence after initial radiotherapy. The purpose of this study is to establish a recurrent esophageal tumor model and investigate radiosensitizing effects of sodium glycididazole (CMNa). Tumor models were established by pre-irradiation (0 Gy, 10 Gy or 20 Gy) to the right hind leg of the nude mice 24 hours before ...

Presenter: John D Karalis MD | University of Texas Southwestern Medical Center Background: Insulinomas are rare neuroendocrine tumors for which surgical resection is the cornerstone treatment. Enucleation insulinomas located in head pancreas can be challenging but preferable to avoid morbidity associated with pancreaticoduodenectomy. Our video-presentation aims describe our technique robotic en...

Mediastinal germ cell tumors (GCTs) are rare and aggressive cancers originating from the cells in mediastinum. Early detection treatment vital due to their high potential for metastasis recurrence. We present a case of 28-year-old man who exhibited cough shortness breath. Laboratory tests revealed elevated tumor markers, alpha-fetoprotein, beta-human chorionic gonadotropin. Imaging studies disp...

Hypoxia, a hallmark of malignant tumors, often correlates with increasing tumor aggressiveness and poor treatment outcomes. Due to a lack of vasculature, effective drug delivery to hypoxic tumor regions remains challenging. Signaling through the chemokine SDF-1α and its receptor CXCR4 plays a critical role in the homing of stem cells to ischemia for potential use as drug-delivery vehicles. To h...

Background: Study in design to incorporate accelerated proliferation correction factors into linearquadratic and multiple-component models. Materials and Methods: Accelerated proliferation rate correction factor has been incorporated into the linearquadratic and the multiple component models by applying accelerated exponential cell growth to explain the tumor cell kinetics and estimates proper ...

Background: Due to abscopal effect, cell damage may occur outside of the radiation field and the quantification of this effect is one of the most challenging debates in radiation therapy. The aim of this study was to estimate the abscopal effect induced in non-irradiated tumors quantitatively by means of biological effective dose (BED). Materials and Methods: Breast tumors using 4T1 and MC4-L2 ...

Reproducing a tumor microenvironment consisting of blood vessels and tumor cells for modeling tumor invasion in vitro is particularly challenging. Here, we report an artificial blood vessel implanted 3D microfluidic system for reproducing transvascular migration of tumor cells. The transparent, porous and elastic artificial blood vessels are obtained by constructing polysaccharide cellulose-bas...