Abstract Background and Aims Acute kidney injury (AKI) is a serious clinical complication that has high morbidity mortality. Although there have been substantial advances in understanding AKI mechanisms, at present, are no effective therapies to treat or prevent it. Method We had formerly found TUG891, GPR120 (a member of the G protein-coupled receptor (GPCR) family) agonist, alleviated tubular...

An efficient approach for the synthesis of a series of S-acyl peptides containing internal cysteine residues has been developed and the chemical long-range ligation of these S-acyl peptides via 5-, 8-, 11- and 14-membered cyclic transition states has been investigated. Our results include the first examples of successful isopeptide ligations starting from S-acyl peptides containing non-terminal...

background : the cause of death is difficult to interpret in a road-traffic accident (rta) victim, because multiple injuries make it difficult to decide on the most fatal lesion, particularly when death is delayed by prompt medical intervention; and secondary haemorrhage, renal failure, fat embolism, systemic infections, myocardial or cerebral infarction – all comes under the potential differen...

to find if some indices have predictive value for renal complications. we conducted a cross sectional and included 80 patients with the age ranged 5-17 years, all with the proven diagnosis of β-thalassemia major. a urine and 5 ml of blood sample were obtained from all of the cases. biochemical indices such as serum levels of creatinine, na, mg, hb, and ferritin and also urine levels of na, mg, ...

in the present study, the effect of core on shear lag phenomenon in tubular structures is investigated. three different tubular structure models including model without core, model with central core and model with central core but eliminated in last 15 stories have been analyzed. a shear lag index is defined for evaluating these models. from examination of the results, the effective influence o...

in this paper, optimization and control of a tubular reactor for thermal bulk post-polymerization of styrene have been investigated. by using the reactor mathematical model, static and dynamic simulations are carried out. based on an objective function including polymer conversion and polydispersity, reactor optimal temperature profile has been obtained. in the absence of model mismatch, desire...

this study was designed to investigate the role of gabab receptor agents on imipramine-induced antinociception in ligated and non-ligated mice using hot-plate test. the data showed that different doses of morphine (3, 6, and 9 mg/kg) induced a dose-dependent antinociception in ligated and non-ligated mice. however, the opioid response was decreased in ligated animals. intracerebroventricular (i...

pseudo-aneurysm of the femoral artery is the most common arterial complication in drug injecting abusers. scholars in vascular surgery have published debating statements regarding techniques of successful surgical management during last two decades. we present the results of simple arterial ligation in a series of 32 patients presenting with infected femoral pseudo-aneurysm. most of the patient...

To study the role of circulating natriuretic factors in the postobstructive diuresis that occurs after relief of bilateral, but not unilateral ureteral ligation, cross-circulation was carried out between normal recipient rats and donor rats have either 24-h bilateral (BUL) or unilateral (UUL) ureteral ligation. With BUL donors, there was a rapid marked increase in sodium and water excretion in ...