Previous studies have investigated the role of Toll-like receptor (TLR)2 and TLR4 in susceptibility to and severity of Chlamydia trachomatis infections. In this study we employ a unique integrated approach to study the role of the intracellular CpG DNA receptor: we use a murine knockout (KO) model to assess TLR9 relevance, study human TLR9 genotypes and haplotypes in sexually transmitted diseas...

Susceptibility to Chlamydia trachomatis infections is 40% host based. microRNA-146a is a negative regulator of Tolllike receptor (TLR) signaling and possesses functional polymorphisms which decrease the production of premiR-146a and mature miR-146a. Single nucleotide polymorphisms (SNPs) in NLRP3 are associated with decreased NLRP3 expression and hypoproduction of interleukin (IL)-1beta. We inv...

Tubal choriocarcinoma is uncommon, and its magnetic resonance imaging characteristics have not yet been reported. In this report, a 39-year-old woman presented with irregular painless vaginal bleeding and a palpable left lower abdominal lump for 2 months following 6 weeks' amenorrhea and positive urine pregnancy test. Her serum β-human chorionic gonadotropin value was significantly increased. U...

Chlamydia trachomatis (Ct) infections have remarkable interindividual differences in the clinical course which are for 40% based on host genetic variation including genes encoding immunoregulatory and bacteria sensing proteins. As patient-related immunomodulating factors, toll-like receptors (TLRs) are closely involved in pathogen recognition and host defence in Ct infections. Here we study the...

We reviewed the place of tubal surgery in the era of assisted reproductive technology. Reversal of tubal ligation is one of the main indications for tubal microsurgery. Adhesiolysis has the best results if the adhesion is the only factor responsible for infertility. There are no differences between adhesiolysis by laparoscopy or by laparotomy, and so laparoscopy must be preferred. Proximal tuba...

Background: Adnexal masses can be either a physiological luteal cyst, benign tubo-ovarian mass or malignancy. The signs and symptoms along with tumour markers imaging modalities are considered to differentiate between malignant adnexal mass. in pregnancy asymptomatic present acute abdomen cases of ectopic torsion. aim was study the prevalence various histopathologic types different age groups. ...

Background: The aim of this study was to find out different causes of female infertility with diagnostic approach using laparoscopy and hysteroscopy. Methods: This retrospective study was done in the Department of Obstetrics and Gynecology of MGMCRI, Puducherry. 135 infertile women aged 19-40 years were enrolled retrospectively for combined laparoscopy and hysteroscopy. These infertile women we...

OBJECTIVE We analyzed the results of laparoscopic tubal surgery performed at the Department of Obstetrics and Gynaecology, University of Kiel, between 1999 and 2000. A retrospective review of 236 tubal surgical procedures was conducted: (1) patients with ectopic pregnancies, unilateral or bilateral tubal occlusions or alterations and (2) medically indicated sterilizations and salpingectomies. ...