The tensile strength (TS) of rocks is an important parameter in the design of a variety of engineering structures such as the surface and underground mines, dam foundations, types of tunnels and excavations, and oil wells. In addition, the physical properties of a rock are intrinsic characteristics, which influence its mechanical behavior at a fundamental level. In this paper, a new approach co...

purpose: to report multiple astrocytic hamartomas in a patient with tuberous sclerosis (ts). patient and findings: a 16-year-old girl with ts without any ocular complaint was referred for ophthalmologic examination. she had papular rash on her face and other skin lesions elsewhere in the body which were specific for ts. multiple well-circumscribed elevated lesions characteristic of astrocytic h...

We estimate “CEO style” wage equations using two longitudinal matched employeremployee data sets. We develop a model in which the wages of all employees in a ...rm are linked to those of top management, which generates speci...c empirical implications that have already been tested on CEOs. We provide evidence that the wages of “regular” employees in large ...rms are linked to accounting and sto...

Folate analogues that inhibit thymidylate synthase (TS) selectively were developed based on TS and folate molecular structures and properties. The structure-activity relationship, preclinical and clinical development, and issues of potential importance in the future success of these TS inhibitors are reviewed herein. Properties of these new compounds depend mainly on the use of the reduced fola...

Folate analogues that inhibit thymidylate synthase (TS) selectively were developed based on TS and folate molecular structures and properties. The structure-activity relationship, preclinical and clinical development, and issues of potential importance in the future success of these TS inhibitors are reviewed herein. Properties of these new compounds depend mainly on the use of the reduced fola...

Folate analogues that inhibit thymidylate synthase (TS) selectively were developed based on TS and folate molecular structures and properties. The structure-activity relationship, preclinical and clinical development, and issues of potential importance in the future success of these TS inhibitors are reviewed herein. Properties of these new compounds depend mainly on the use of the reduced fola...