Purpose:Mechanisms mediating androgen receptor (AR) reactivation in prostate cancer that progresses after castration (castration-resistant prostate cancer; CRPC) and subsequent treatment with abiraterone (CYP17A1 inhibitor that further suppresses androgen synthesis) remain unclear. Experimental Design: Prostate cancer xenografts were examined to identify mechanism of progression after castratio...

Local dry/wet conditions are of great concern in regional water resource and floods/droughts disaster risk management. Satellite-based precipitation products have greatly improved their accuracy and applicability and are expected to offer an alternative to ground rain gauges data. This paper investigated the capability of Tropical Rainfall Measuring Mission (TRMM) rainfall data for monitoring t...

PURPOSE Enzalutamide, a second-generation antiandrogen, was recently approved for the treatment of castration-resistant prostate cancer (CRPC) in patients who no longer respond to docetaxel. Despite these advances that provide temporary respite, resistance to enzalutamide occurs frequently. Androgen receptor (AR) splice variants such as AR-V7 have recently been shown to drive castration-resista...

Castration-resistant prostate cancer (CRPC) progresses rapidly and is incurable. Constitutively active androgen receptor splice variants (AR-Vs) represent a well-established mechanism of therapeutic resistance and disease progression. These variants lack the AR ligand-binding domain and, as such, are not inhibited by androgen deprivation therapy (ADT), which is the standard systemic approach fo...

Purpose: Enzalutamide, a second-generation antiandrogen, was recently approved for the treatment of castration-resistant prostate cancer (CRPC) in patients who no longer respond to docetaxel. Despite these advances that provide temporary respite, resistance to enzalutamide occurs frequently. Androgen receptor (AR) splice variants such as AR-V7 have recently been shown to drive castration-resist...

The Tropical Rainfall Measuring Mission (TRMM) is a NASA satellite project initiated to address a gap in our ability to accurately observe detailed rainfall patterns over the tropical continents and oceans. To support TRMM, several field campaigns were conducted. The TRMM-LBA (Large-scale Biosphere Atmosphere) experiment was conducted over the southwestern region of the Amazon (state of Rondôni...

Accurate estimation of rainfall in mountainous areas is necessary for various water resource-related applications. Though rain gauges accurately measure rainfall, they are rarely found in mountainous regions and satellite rainfall data can be used as an alternative source over these regions. This study evaluated the performance of three high-resolution satellite rainfall products, the Tropical ...

A study was performed using the first full year of rain gauge records from a newly deployed network in the Southern Appalachian mountains. This is a region characterized by complex topography with orographic rainfall enhancement up to 300% over small distances (<8 km). Rain gauge observations were used to assess precipitation estimates from the Precipitation Radar (PR) on board of the TRMM sate...

This study utilizes TRMM satellite precipitation radar, lightning imaging sensor, and passive microwave imager data together with ground-based lightning data to investigate the vertical structure, lightning, and rainfall characteristics of Amazonian and sub-tropical South American convection for three separate wet-seasons. These characteristics are partitioned as a function of 850 mb zonal wind...