From the roots of Adina rubella, four new quinovic acid glycosides, quinovic acid 3-O-beta-D-glucopyranosyl(1-->4)-beta-D-fucopyranoside, quinovic acid 3-O-beta-D-glucopyranosyl(1-->4)-beta-D-fucopyranosyl-(28-->1)-beta-D- glucopyranosyl ester, quinovic acid 3-O-beta-D-glucopyranosyl(1-->4)-alpha-L-rhamnopyranosyl-(28-->1) -beta-D-glucopyranosyl ester and quinovic acid 3-O-beta-D-glucopyranosyl...

A new triterpenoid saponin, named stauntoside A (1) along with four known saponins (2,3,4,5) was isolated from Stauntonia chinensis DC., (Lardizabalaceae). Their structures were elucidated by spectroscopic analysis and chemical methods as 3-O-alpha-L-arabinopyranosyl-30-norhederagenin -28-O-beta-D-glucopyranosyl-(1 --> 6)-beta-D-glucopyranosyl ester (1), 3-O-alpha-L-arabinopyranosyl-30- norhede...

The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1, 9(11)-dien-28-oyl]imidazole (CDDO-Im) is a multifunctional agent with potent anti-inflammatory, antiproliferative, cytoprotective, and apoptotic activities, whose molecular targets are unknown. Using both cell-free and cellular assays, we show that CDDO-Im is a direct inhibitor of IKB kinase (IKK) B and that it thereby inhibits binding o...

Five novel iridal-type triterpenoid derivatives, including three unprecedented adducts of spiroiridal and isoflavonoid, named belamcandanins A–C (1–3), one unprecedented iridal lactone, named belamcanolide A (4), and one new and rare iridal epoxide, named belamcanoxide A (5), have been isolated from the rhizomes of Belamcanda chinensis, along with five known compounds. Their structures were elu...

Antihypertensive herbs in scientification of “jamu” program in Indonesia contained Centella asiatica (L.) Urban. The leaf contains several compounds such as triterpenoids, flavonoids, phenolics, tannins, and resins. The total triterpenic fraction of C. asiatica could treat venous hypertensive microangiopathy, while ethyl acetate fraction of C. asiatica leaf has hypotensive effect in cats. This ...

A hexane extract of Plantago major was investigated by bioactivity-directed fractionation, using an in vitro cyclooxygenase-2 (COX-2) catalyzed prostaglandin biosynthesis inhibition assay, and resulted in the isolation of ursolic acid (1). This triterpenoid showed a significant COX-2 inhibitory effect, directly on the enzyme activity, with an IC50 value of 130 microM and a COX-2/COX-1 selectivi...

Biosynthetic investigation of quinonemethide triterpenoid 22β-hydroxy-maytenin (2) from in vitro root cultures of Peritassa laevigata (Celastraceae) was conducted using (13)C-precursor. The mevalonate pathway in P. laevigata is responsible for the synthesis of the quinonemethide triterpenoid scaffold. Moreover, anatomical analysis of P. laevigata roots cultured in vitro and in situ showed the p...

From the ethanol extract of the stem of Lecaniodiscus cupanioides Planch, two known compounds 1 and 2 were isolated and identified as triterpenoid saponins 3-O-[α-L-arabinofuranosyl- (1→3)-α-L-rhamnopyranosyl- (1→2)-α-L-arabinopyranosyl-]-hederagenin and 3-O- [α-L-arabinopyranosyl- (1→3)-α-L-rhamnopyranosyl (1→2)-α-L-arabinopyranosyl-]-hederagenin. The structures were established by physicochem...