Triptolide, a biologically active natural product from Tripterygium wilfordii, protects neurons from inflammation-mediated damage. Our results showed for the first time that triptolide inhibited the expression of CXCR2 and presenilin in a neuroblastoma cell line SHSY5Ysw. Moreover, triptolide potently inhibited amyloid-β1-42 production with IC50 value of 30 pM in HEK293sw cells or 2 nM in SHSY5...

Cases of Henoch-Schönlein purpura and purpura nephritis accompanied by pulmonary hemorrhage are rare. Mild cases are easily ignored due to a lack of evident bleeding, and severe cases may be fatal. We have only treated one patient with Henoch-Schönlein nephritis (HSPN), a female child. The clinical manifestations were not evident, however, the imaging manifestations were clear. Finally, the pat...

A capillary electrophoresis method has been established for the determination of triptonide and triptolide in Multi-glycosides Tripterygium wilfordii tablets. Capillary separation was carried out by using 0.01mol L borax + 0.02 mol L boric acid + 0.02 mol L SDS (pH = 8.0) as the buffer, a fused – silica capillary tube column (60.2 cm × 75μm id. 52.6 cm of effective length) as the separation cha...

To investigate the effect and mechanism of Tripterygium wilfordii polyglycosides on rheumatoid arthritis rats by regulating signal transducer activator transcription 3 pathways. 45 specific-pathogen free male Sprague-Dawley were randomly divided into normal control group, model group with 15 in each group. The histopathological changes synovium ankle joint 12th, 20th 28th d compared. On 12th d,...