Key points Dysfunctions in the hypoglossal control of tongue extrinsic muscles are implicated obstructive sleep apnoea (OSA) syndrome. Chronic intermittent hypoxia (CIH), an important feature OSA syndrome, produces deleterious effects on motor oropharyngeal resistance, but whether motoneurones innervating affected by CIH is unknown. We show that enhanced respiratory‐related activity rat nerve p...

The formation of the mitotic spindle is a complex process that requires massive cellular reorganization. Regulation by mitotic kinases controls this entire process. One of these mitotic controllers is Aurora A kinase, which is itself highly regulated. In this study, we show that the nuclear pore protein ALADIN is a novel spatial regulator of Aurora A. Without ALADIN, Aurora A spreads from centr...

Poland syndrome is a rare congenital disease characterized by various degrees of chest wall defects, such as deficits in the small thoracic muscle and defects neuromuscular region muscle. In addition, this condition may present with loss or weak development papilla breasts can be accompanied brachydactyly, syndactyly, limb hands feet on same side. also cause deformities heart, lungs, kidneys. T...

Objective(s):Hypoxia induces cellular oxidative stress that is associated with neurodegenerative diseases. Here, the protective effects of ferulic acid (FA) on hypoxia-induced neurotoxicity in PC12 cells were evaluated. Materials and Methods:We investigated the effect of FA on PC12 cells subjected to hypoxia stress, in vitro. Results:FA increased cell viability, prevented membrane damage (LDH r...

PURPOSE Hepatopulmonary syndrome is an arterial oxygenation disorder brought about by advanced liver failure and pulmonary vascular dilatations. The reason why hypoxia develops in hepatopulmonary syndrome depends on the broadening of perialveolar capillary veins. Our study aims to investigate the effects of Flavanoid on hepatopulmonary syndrome through its inhibition of nitric oxide. METHODS ...