Research concerning oligonucleotide-directed triple helix formation has mainly focused on the binding of DNA oligonucleotides to duplex DNA. The participation of RNA strands in triple helices is also of interest. For the pyrimidine motif (pyrimidine.purine.pyrimidine triplets), systematic substitution of RNA for DNA in one, two, or all three triplex strands has previously been reported. For the...

The relationship between the university-the enterprise and the government evolved towards the Triple Helix model and allowed, through a new strategy of innovating University, the understanding of the research work as researching at risk, this is the integration of the scientific production and the management of the results as a global tool, which means the generation of knowledge plus the gener...

The knowledge society of today is characterized by a continuously ongoing technological development and digitalization that steadily calls for new competencies and transforms existing professions. For being able to provide up-to-date competence in a fast-changing labor market there is, perhaps more than ever, a need for extensive cooperation between Universities and surrounding society. A numbe...

Simian retrovirus type-1 uses programmed ribosomal frameshifting to control expression of the Gag-Pol polyprotein from overlapping gag and pol open-reading frames. The frameshifting signal consists of a heptanucleotide slippery sequence and a downstream-located 12-base pair pseudoknot. The solution structure of this pseudoknot, previously solved by NMR [Michiels,P.J., Versleijen,A.A., Verlaan,P...

Abstract While the Triple Helix and Quadruple models are popular in innovation studies, relations between them have not been addressed extensively literature. There diverse interpretations of helix empirical studies that apply them, but these sometimes deviate from original theses models. Such a situation can confuse newcomers to field terms which model their research. We discern cause this res...