Book Reviews folded up correctly. Of course, these are only a few of the structural biology milestones that have been reached in the last few years, and as much as we cannot afford to mention them all here, Tsonis's book attempts its best Anatomy of Gene Regulation—A Three-to do so. of the main body accompanies the reader through the 282 pp. $50.00 biology. A very useful lending hand is provide...

Tiazofurin is a synthetic "( " nucleoside analogue with a promising spectrum of experimental antitumor activity and a relatively novel mech anism of action. Previous work in our laboratories had revealed indica tions of collateral sensitivity and therapeutic synergism for selected murine tumor models treated with tiazofurin alone or in combination with an antimetabolite or an alkylating agent. ...

which induces cascades of intracellular signaling events, including protein phosphorylation and cytoskel-etal reorganization (Schwartz et al., 1995; Shattil and Ginsberg, 1997). However, ligand binding to integrins is not simply controlled by ligand availability but also through " inside-out " signaling: cellular stimulation clus-3 Joseph J. Jacobs Center for Thrombosis and ters integrins or al...

Editor's Note: These short, critical reviews of recent papers in the Journal, written exclusively by graduate students or postdoctoral fellows, are intended to summarize the important findings of the paper and provide additional insight and commentary. For more information on the format and purpose of the Journal Club, please see Review of Friedman et al. The two major cellular mechanisms respo...

although the latter is more potent and has a isolated caudate slices by one minute longer plasma half-life.3 exposure to 20mM K' induced a tritium Given their mild D2 blocking effect in overflow of 3-9% of tissue content. Cinnaaddition to their calcium entry channe. rizine, flunarizine and nifedipine at doses antagonist activity, it has been speculated able to block calcium channels lowered the...

conditioning in the isolated nervous system is attenuated in presence of the NMDA receptor antagonist APV. This finding is consistent with the results of Lin and Glanzman (1994), which indicated that the influx of calcium through NMDA receptors in the postsynaptic neu-ron is necessary for facilitation, and suggests that a Houston, Texas 77030 Hebbian mechanism is important for classical conditi...

In addition, CD4 can induce conformational changes in the viral glycoproteins, as measured by antibody epi-Department of Microbiology School of Medicine tope changes and gp120 shedding from the virus (reviewed by Sattentau and Moore, 1993), but viral binding and these conformational changes are not sufficient for HIV-1 infection of cells. In nonhuman cells expressing Binding of virus particles ...

Evidence is presented that inhibition of 12-O-tetradecanoylphorbol13-acetate (TPA)-induced ornithine decarboxylase (OIK ; EC 4.1.1.17) by retinoic acid may involve inhibition of protein kinase C-mediated synthesis of ODO mRINA. A single application of 10 nmol of TPA to intact mouse skin led to an increase in the steady state levels of epidermal ODC iiiHN \; a maximal level of ODC niRNA occurred...

were excluded. Patients for whom outcome information was not obtained also were excluded. Methods bulance services transporting to 7 hospitals in 3 counties in southeastern Michi-Study Design: We performed a mul-To Edi'oc-sPinal injury is ticenter, prospective, out-of-hospital, ob-gan. Three of the hospitals treat major one of the most devastating potential out-servational study to estimate the...

To the Editor: Electrical stimulation of the cerebellar fastigial nucleus (FN) in rat reduces, by over 40%, the vol­ ume of the focal ischemic infarction produced by occlusion of the middle cerebral artery (MCA) (Berger et aI. , 1990; Reis et aI. , 1991; Zhang and Iadecola, 1992; Yamamoto et aI. , 1993). The mech­ anism of the effect is unknown. While the salvage has been attributed to neuronal...