The molecular mechanisms regulating recruitment of intracellular signaling proteins like growth factor receptor-bound protein 2 (Grb2), phospholipase Cgamma1, or phosphatidylinositol 3-kinase (PI3-kinase) to the plasma membrane after stimulation of the T cell receptor (TCR)- CD3-zeta complex are not very well understood. We describe here purification, tandem mass spectrometry sequencing, molecu...

PURPOSE Diabetes is a debilitating illness requiring lifelong management. Treatments can be varied in terms of mode of administration as well as type of agent. Unfortunately, most patient reported outcome measures currently available to assess the impact of treatment are specific to diabetes type, treatment modality or delivery systems and are designed to be either a HRQoL or treatment satisfac...

Tripartite motif (TRIM) proteins constitute a family of over 100 members that share conserved tripartite motifs and exhibit diverse biological functions. Several TRIM proteins have been shown to restrict viral infections and regulate host cellular innate immune responses. In order to identify TRIM proteins that modulate the infection of hepatitis B virus (HBV), we tested 38 human TRIMs for thei...

Introduction Proximal trim lines for trans-tibial prosthetic sockets have traditionally been trimmed according to the mode of suspension to the limb. The supracondylar suspension, which retains the prosthetic socket to the limb by gripping above the femoral condyles, has a more proximal trim line compared to the more distal trim line used for a suspension with a patellar-tendon-bearing strap or...

Automatic trajectory planners require knowledge of an aircraft’s flight envelope to ensure their solution is feasible. Existing flight management systems presume a nominal performance envelope, requiring online identification or characterization of any performance degradation. Given predictable failures such as a control surface jam, we can evaluate stability and controllability offline to esta...

Recent work from our laboratory revealed that tryptic soy broth (TSB) was a superior enrichment medium for use in test-and-hold Escherichia coli O157:H7 methods at levels down to a ratio of three volumes of medium to one volume of sample. Lower ratios were examined for their effect on results obtained from culture isolation, the BAX E. coli O157:H7 MP assay, and the Assurance GDS E. coli O157:H...

Because the regulation of vascular function involves complex mutual interactions between nitric oxide (NO) synthase (NOS) and cyclooxygenase (COX) products, we examined the contribution of NO and prostanoids derived from the COX pathway in modulating aortic baroreceptor resetting during an acute (30 min) increase in arterial pressure in anesthetized rats. Increase in pressure was induced either...

Since the regulation of vascular function involves complex mutual interactions between NO synthase (NOS) and cyclooxygenase (COX) products, we examined the contribution of NO and prostanoids derived from the COX pathway in modulating aortic baroreceptor resetting during an acute (30 min) increase in arterial pressure in anesthetized rats. Increase in pressure was induced either by administratio...

Multiple linear regression equations were developed for predicting the percentage of fat content of beef and pork. The predictor variables were bioelectrical resistance, temperature, and weight of product. Equations were developed for trim and product ground through a .95- or a .32-cm plate. The trim, .95-cm, and .32-cm grinds had 64, 108, and 96 observations, respectively, for beef product and...