We examined the functional organization of the rat trigeminal nuclear complex and its developmental dynamics using a multiple-site optical recording technique. Brainstem preparations were dissected from embryonic day 12 (E12)-E16 rat embryos, and stimulation was applied individually to the three branches of the trigeminal nerve (V1-V3). The action potential activity of presynaptic fibers was de...

The mode of action of onabotulinumtoxinA in the treatment of chronic migraine is suggested to In the early 1900s, Weiller and his group elegantly demonstrated that during a Schematic presentation of the trigeminovascular system. branches of the trigeminal nerves and the greater and lesser occipital nerve branches. An Early Symptom of Multiple Sclerosis Trigeminal neuralgia can be a source of ex...

BACKGROUND The evaluation of the trigeminal course and his anatomical relationships with surrounding structures, is important for the assessment of the injury that may occur in tumors and several orofacial trauma and for avoiding the damage during surgeries. AIM The aim of this retrospective study was to assess the use of 3-T MRI in the evaluation of the course of the four segments of the tri...

BACKGROUND We investigated the role of the central NMDA receptor NR2 subunits in the modulation of nociceptive behavior and p-p38 MAPK expression in a rat model with compression of the trigeminal nerve root. To address this possibility, changes in air-puff thresholds and pin-prick scores were determined following an intracisternal administration of NR2 subunit antagonists. We also examined effe...

OBJECTIVE To search for correlations between specific anatomic, geometric, and morphological properties of the trigeminal nerve and the success of radiosurgical treatment and elimination of facial hypesthesia as a complication. METHODS Forty-six patients with at least 6 months of follow-up after CyberKnife (Accuray, Inc., Sunnyvale, CA) rhizotomy were retrospectively reviewed. Patients treate...

Neonatal damage to the trigeminal nerve leads to "reactive synaptogenesis" in the brain stem sensory trigeminal nuclei. In vitro models of brain injury-induced synaptogenesis have implicated an important role for astrocytes. In this study we tested the role of astrocyte function in reactive synaptogenesis in the trigeminal principal nucleus (PrV) of neonatal rats following unilateral transectio...

Although pharmacological therapy is the primary treatment modality for trigeminal neuralgia associated pain, ineffective analgesia and dose limiting side effects often prompt patients to seek alternative pharmacological solutions such as interventional nerve blockade. Blockade of the Gasserian ganglion or its branches is an effective analgesic procedure for trigeminal neuralgia, traditionally p...

A patient with epilepsy was shown to have neurobiological, psychological, cognitive, and social issues as a result of recurring seizures, which is regarded to be a chronic brain disease.However, despite numerous drug treatments, approximately, 30–40% of all patients are resistant to antiepileptic drugs. Therefore, newer therapeutic modalities are introduced into clinical practice in which invol...

Thirty-six cases of petroclival meningiomas with clearly defined anatomical features were selected to analyze the site of tumor attachment and the displacement of the trigeminal nerve. The tumors were classified into four categories according to the origin and extension of the tumor: clival origin medial to the trigeminal nerve (upper clivus type), clival origin with dumbbell extension to the c...

Trigeminal neuralgia is a recognized complication in patients with intracranial tumours affecting the trigeminal nerve. This case report describes an epidermoid tumour at the cerebellopontine angle in a middle-aged man with otherwise classical unilateral trigeminal neuralgia. The case highlights the difficulties of diagnosis and the importance of a multidisciplinary approach when trigeminal neu...