objective: the present study was designed to investigate the putative antidepressant effects of crocin and crocetin, two major active ingredients of crocus sativus l. (saffron) using mice in two different regimens of acute and sub-acute administration. material and methods: in acute treatment, antidepressant-like activities of crocin and crocetin (10, 20 and 40 mg/kg, i.p.) were evaluated using...

Editorial Sexual dysfunction is a common side effect of psychotropic drugs and has received much attention because of its negative effects on quality of life and adherence to antidepressant agents. In patients with depression, sexual dysfunction can be attributed to the underlying disorder or to antidepressant drugs. Sexual dysfunction also can occur with first generation antipsychotic drugs an...

Objective(s) This study planned to assess antidepressant like activity of aqueous extract from leaves of Citrus maxima Merr. (Rutaceae). Materials and Methods Boiling was used for aqueous extraction. Acute toxicity study was performed in mice. Antidepressant activity was studied using locomotor activity test, modified forced swimming test (FST) and tail suspension test (TST). Three doses 100...

Introduction: Depressive disorder is a prevalent psychiatric disorder, which affects 21% of the world population. The presently using drugs can impose a variety of side-effects including cardiac toxicity, hypopiesia, sexual dysfunction, body weight gain, and sleep disorder. During the last decade, there is a growing interest in the therapeutic effects of natural products on mental disorders. Am...

OBJECTIVE Even though there are many drugs for the treatment of gastric ulcers, these drugs sometimes cannot succeed. Since the 1950s, antidepressant drugs have been used for several non-psychiatric indications. Many antidepressant drugs have been shown experimentally to produce antiulcer activity in various ulcer models. Moclobemide is an antidepressant drug which inhibits monoamine oxidase-A ...

AIMS To explore the gender- and age-specific risk of developing a first myocardial infarction in people treated with antidiabetic and/or antidepressant drugs compared with people with no pharmaceutical treatment for diabetes or depression. METHODS A cohort of all Swedish residents aged 45-84 years (n = 4 083 719) was followed for a period of 3 years. Data were derived from three nationwide re...

OBJECTIVE The aim of this analysis was to delineate trends in spontaneous postmarketing reporting data with antidepressant drugs for adverse events involving suicidal behaviors in children and adolescents. METHODS The U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (AERS) was searched for postmarketing adverse event reports of suicidal thoughts and behaviors occurring i...

Major depressive disorder (MDD) is a debilitating and often recurrent psychiatric illness that impacts the lives of millions. Approximately 20 percent of individuals will experience at least one depressive episode during their lives, and the high rates of chronic morbidity (depressive episodes typically last for several months) and mortality (owing to suicide) attributed to this disorder consti...

BACKGROUND There is increasing evidence that glial cells play a role in the pathomechanisms of mood disorders and the mode of action of antidepressant drugs. METHODS To examine whether there is a direct effect on the expression of different genes encoding proteins that have been implicated in the pathophysiology of affective disorders, primary astrocyte cell cultures from rats were treated wi...

Long known for their mood altering effects, cannabinoids are currently under investigation for their therapeutic potential in the treatment of depression. Findings from multiple areas of basic research indicate that this system is indeed a viable target for novel antidepressant drugs. Rodent models of depression have been shown to alter levels of the endogenous cannabinoids and the cannabinoid ...