purpose: to evaluate the influence of different confounding factors on the effect of intravitreal triamcinolone acetonide injection for refractory diabetic macular edema. methods: in a prospective placebo-controlled randomized clinical trial, 88 eyes with refractory diabetic macular edema were randomly assigned into two groups including 45 in the treatment group (4 mg intravitreal triamcinolone...

conclusions this study showed that topical glycyrrhiza glabra appeared to be a promising alternative in the treatment of olp. further studies should be conducted to assess the long-term effects of glycyrrhiza glabra. objectives the aim of this study was to compare the efficacy and safety of 1% glycyrrhiza glabra in orabase with 0.1% triamcinolone acetonide paste in treating oral lichen planus (...

Novel formulations of the halogenated corticosteroid, triamcinolone-acetonide, based on ultradeformable mixed lipid vesicles, Transfersomes, are described. Their performance was tested in vivo using radioactive label measurements, to study the drug biodistribution, and murine ear edema, to determine the drug bioactivity. Sparse use of drug-loaded Transfersomes on the skin ensures an almost excl...

Introduction. Alopecia areata (AA) is a chronic inflammatory disease that involves hair follicles, and sometimes nails, caused by a T-cell mediated autoimmune mechanism. Current treatment modalities include corticosteroids (oral, topical or intralesional), minoxidil, contact sensitizers (DNCB, DPCP and SADBE), immunosuppressants (methotrexate or azathioprine), DMARDs (sulfasalazine), and photot...

Corticosteroids are recommended for emergency management of an asthmatic attack. This study was designed to compare the effectiveness of oral and intramuscular steroid on spirometric results in acute asthma. We performed a randomized trial involving 88 adults, aged 15-70 years, with acute exacerbation of asthma requiring treatment with steroids. All had been treated with standard bronchodilator...

background: cystoid macular edema (cme) is one of the most common and sight threatening complications of uveitis. intravitreal injection of corticosteroids and anti-vegf antibody are two routine options for treatment. objective: to compare the effects of intravitreal injections of bevacizumab and triamcinolone acetonide for the treatment of persistent macular edema in non-infectious uveitis. me...

PURPOSE To compare the intravitreal pharmacokinetic profile of a triamcinolone acetonide formulation containing the preservative benzyl alcohol (TA-BA) versus a preservative-free triamcinolone acetonide formulation (TA-PF), and evaluate potential signs of toxicity to the retina. METHODS A total of 60 New Zealand male white rabbits, divided into two groups, were studied. In the TA-BA group, 30...

BACKGROUND Chronic rhinosinusitis (CRS) is an inflammatory process that causes different clinical symptoms: nasal blockage and congestion, posterior and anterior nasal drip, and smell disorder ranging from reduced olfaction (hyposmia) to complete loss of smell (anosmia). It has been suggested that mechanical blockage of olfactory clef after polypectomy is responsible for the persistent impairme...

OBJECTIVE Evaluation of gait performance and muscle activity patterns as well as clinical efficacy and safety after single intraarticular injection with hyaluronan compared with triamcinolone in patients with knee osteoarthritis. MATERIALS AND METHODS This trial evaluated the influence of a single injection of hyaluronan or triamcinolone on gait pattern and muscle activity. For clinical evalu...

Dear Editor: Miyamoto et al show that intravitreal triamcinolone reduces macular edema as early as 1 hour after injection. They suggest that the time pattern demands that nongenomic mechanisms must be involved in the therapeutic effect of triamcinolone on retinal edema. Vasogenic edema in all tissues, including the retina, may be understood in terms of Starling’s law, by which the balance of hy...