Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide and leads serious longterm disability. To determine the effect of hydrogen-rich water on the angiogenesis in the lesion boundary brain tissue of TBI-challenged rats, 54 adult male Sprague-Dawley (SD) rats were used and randomly divided into three groups: sham-operated, TBI (Traumatic brain injury) and TBI+HW (Tra...

Disruptions in sleep-wake cycles are particularly prevalent after a Traumatic Brain Injury (TBI). Sleep disruptions may occur as main impact of brain damage or result other neuropsychiatric sequelae TBI, such anxiety disorder, depressive disorders, substance abuse, chronic pain, and/or medication consumption. Chronic discomfort (headache and broad presumably central origin) sleep difficulties (...

introduction: brain injury is an important cause of morbidity and mortality worldwide and so far, there has been no absolute treatment for the damaged brain tissue. using human stem cells with self-assembling scaffolds can be a promising method for treatment of traumatic brain injury. materials and methods: human meningioma stem cells were isolated, cultured and then expanded into in vitro cond...

Introduction: Recent studies have reported that the Aloe vera (Aloe barbadensis miller) plant has anti-inflammatory and antioxidant effects. This study evaluated the neuroprotective effects of different doses of Aloe vera extract after traumatic brain injury (TBI) in male rats. Materials and Methods:  In this study, 70 male rats were divided into 2 groups; each group consists of 5 of sub-g...

Traumatic brain injury (TBI) is physical damage to the brain structure which has a high global rate of mortality and morbidity. TBI can cause intense inflammatory response due to accumulation of leukocytes in cerebral matrix and activation of microglia. Microglia can differentiate into M1 macrophages or M2 macrophages following the changes in biochemical properties of brain tissue. M1 sub type ...

This commentary discusses traumatic brain injury (TBI) related to falls among elderly individuals, as well as common TBI sequelae and their treatment. It also discusses the current understanding of TBI-related dementia and chronic traumatic encephalopathy.

Traumatic brain injury (TBI) is a common, preventable, and disabling health condition with heterogeneous aetiology, type, severity, and outcomes. Ongoing challenges in TBI care are reflected by rapidly growing literature in the prevention, assessment and treatment of TBI, especially in sports concussion and blast-related TBI. Recent advances include TBI modelling, to predict outcomes of TBI and...

OBJECTIVE Develop and validate a predictive model of the incidence of long-term disability following traumatic brain injury (TBI) and obtain national estimates for the United States in 2003. DATA/METHODS: A logistic regression model was built, using a population-based sample of persons with TBI from the South Carolina Traumatic Brain Injury Follow-up Registry. The regression coefficients were a...

Secondary insults such as brain edema are an important and relatively common event occurring after traumatic injury (TBI), leading to consequences raised intracranial pressure cerebral herniation. Further, posttraumatic inflammatory changes known significantly contribute neuronal dysfunction.

Mitochondria play a central role in cerebral energy metabolism, intracellular calcium homeostasis and reactive oxygen species generation and detoxification. Following traumatic brain injury (TBI), the degree of mitochondrial injury or dysfunction can be an important determinant of cell survival or death. Literature would suggest that brain mitochondria from the developing brain are very differe...