Abstract We report an innovative treatment strategy for fetal Ebstein’s anomaly with a circular shunt. used transplacental non-steroidal anti-inflammatory drugs, at the 29th gestational week, to constrict ductus arteriosus avoiding demise. addressed critical neonate urgent Starnes procedure. Finally, instead of following usual single-ventricle palliation pathway after procedure, we achieved suc...

Dose-response relationships of transplacental tumor induction with the resorptive carcinogen, ethylnitrosourea, were investigated in Sprague-Dawley and Fischer rats. Neuroectodermal tumors were produced in offspring of all rats exposed to a single dose of ethylnitrosourea, 1, 5, 20, or 50-mg/kg, near the end of gestation. The incidence of experimentally induced neoplasms was directly proportion...

Epidemiological studies suggest that smoking during pregnancy and passive exposure of children to cigarette smoke may increase the cancer risk in children and young adults. We have previously shown that the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is an active transplacental carcinogen in Syrian golden hamsters when administered by s.c. injections to pre...

Toxoplasma gondii and Sarcocystis neurona are protozoan parasites with terrestrial definitive hosts, and both pathogens can cause fatal disease in a wide range of marine animals. Close monitoring of threatened southern sea otters (Enhydra lutris nereis) in California allowed for the diagnosis of dual transplacental transmission of T. gondii and S. neurona in a wild female otter that was chronic...

Vesicular stomatitis virus caused transplacental infection in ferrets, resulting in infant death. No clinically significant illness was observed in the adult, despite histological changes in the uterus, liver, and spleen.

Polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene (BaP) are ubiquitous environmental pollutants found in tobacco smoke, air pollution, and grilled foods. Prenatal exposure to BaP causes premature reproductive senescence in mice, and other PAHs are transplacental ovarian carcinogens. Glutathione (GSH) is critical for detoxification of the reactive metabolites of PAHs. Therefore, we h...

Transplacental exposure to carcinogenic air pollutants from the combustion of fossil fuels is a growing health concern, given evidence of the heightened susceptibility of the fetus. These mutagenic/carcinogenic pollutants include aromatic compounds such as polycyclic aromatic hydrocarbons that bind to DNA, forming chemical-DNA adducts. We have investigated the genotoxic effects of transplacenta...