The translocation of secretory and membrane proteins across the endoplasmic reticulum (ER) membrane is mediated by co-translational (via the signal recognition particle (SRP)) and post-translational mechanisms. In this study, we investigated the relative contributions of these two pathways in trypanosomes. A homologue of SEC71, which functions in the post-translocation chaperone pathway in yeas...

iranian cave barb (iranocypris typhlops, bruun and kaiser, 1944)is one of thevery rareandendemicspeciesof iran. its distributionrangeislimitedina habitat that causes some problems for its conservation. thisuniquehabitatfaces somenatural and humanthreatsand the habitatdestructionmeansthe extinctionof the species. based on, habitat selection for translocation of the species is an important object...

This study aimed to evaluate concentrations of selected heavy metals in the soils of Ilokun dumpsite and adjourning farmlands, and to determine as well levels of heavy metals uptake in various parts of Carica papaya plant collected from the dumpsite. Twenty-two soil samples were collected within the dumpsites and farmlands at depths of 0-20 cm and 20-40 cm. Evaluations of heavy metals ...

Palindromes are two groups of identical sequences which join each other in inverted direction. The palindrome mediated genomic instability contributes to a diverse group of genomic rearrangements like translocations, deletions, and amplifications. Palindrome involve in translocation have AT richness (PATRRs) and the best suited examples of this is t(11;22) translocation. PATRR22 is a hotspot of...

BACKGROUND Melanotic Xp11 translocation renal cancer is a rare tumor belonging to the family of microphthalmia-associated transcription factor (MiTF)/transcription factor E (TFE) neoplasms. This tumor family also includes alveolar soft part sarcoma, perivascular epithelioid cell neoplasms, Xp11 translocation renal cell carcinoma, and melanoma. To date, six confirmed melanotic Xp11 translocation...

a cytogenetic study was performed on 11 tetraploid cotton cultivars (gossypium hirsutum l.)including the oltan cultivar and its crossing progenies. the chromosome pairing and chiasma frequency, aswell as meiotic abnormalities were compared among the genotypes studied. heterozygote translocations withalternate orientation were observed between some of the chromosomes of the a genome and those of...

this paper provides information on the geographic distributions of two cyprinid species: hemiculter leucisculus (basilewsky, 1855) and alburnus caeruleus heckel, 1843, in the world and the entire drainage systems in iran. the new distribution records were taken from maroon river (jarrahi river system) and chardaval river (karkheh river system), both in tigris river basin showing wide and narrow...

abstract chromosomal translocations constitute one of the most important, yet uncommon, causes of primary amenorrhea and gonadal dysgenesis. although x-autosome translocations are frequently associated with streak gonads and clinical features of the turner syndrome, the majority of x-autosome carriers may present with a variable phenotype, developmental delay, and recognizable x-linked syndrome...

BACKGROUND Budding yeasts are often used to secrete foreign proteins, but the efficiency is variable. To identify roadblocks in the yeast secretory pathway, we used a monomeric superfolder GFP (msGFP) as a visual tracer in Saccharomyces cerevisiae and Pichia pastoris. RESULTS One roadblock for msGFP secretion is translocation into the ER. Foreign proteins are typically fused to the bipartite ...

The thylakoid transmembrane DeltapH is the sole energy source driving translocation of precursor proteins by the DeltapH/Tat machinery. Consequently, proton translocation must be coupled to precursor translocation. For the precursor of the 17 kDa protein of the oxygen-evolving complex (pOE17), the protein translocation process is characterized by a steep drop in efficiency at an external pH bel...