T he common justification for much research funding is that the outcomes will move from the laboratory to the clinic and patient care, or be converted into jobs and money. The term “translational research” is widely used in this context by medical research institutes and an increasing number of university departments to convey the message to politicians and taxpayers that research activities ul...

Translational research encompasses the effective movement of new knowledge and discoveries into new approaches for prevention, diagnosis, and treatment of disease. There are many roadblocks to successful bench to bedside research, but few have received as much recent attention as the "valley of death". The valley of death refers to the lack of funding and support for research that moves basic s...

Increased interest in the potential societal benefit of incorporating health economics as a part of clinical translational science, particularly nutrition interventions, led the Office of Dietary Supplements at the National Institutes of Health to sponsor a conference to address key questions about the economic analysis of nutrition interventions to enhance communication among health economic m...

UNLABELLED BACKGROUND Clinical translational medicine (CTM) is an emerging area comprising multidisciplinary research from basic science to medical applications and entails a close collaboration among hospital, academia and industry. FINDINGS This Session focused discussing on new models for project development and promotion in translational medicine. The conference stimulated the scientif...

In 2012, the Annual General Meeting of the Clinical Investigator Trainee Association of Canada - Association des cliniciens-chercheurs en formation du Canada (CITAC - ACCFC) and the Canadian Society of Clinician Investigators (CSCI) was held 19-21 September in Ottawa. Several globally-renowned scientists, including 2012 Friesen International Prize recipient, Dr. Marc Tessier-Lavigne, the CSCI/R...

Translational medicine is the integrated application of innovative pharmacology tools, biomarkers, clinical methods, clinical technologies and study designs to improve disease understanding, confidence in human drug targets and increase confidence in drug candidates, understand the therapeutic index in humans, enhance cost-effective decision making in exploratory development and increase phase ...

We would like to welcome you to Journal of Biomedical Semantics (JBMS), a new openaccess, peer-reviewed inter-disciplinary journal that addresses novel theoretical and practical advances in biomedical semantics research. The main focus of JBMS is the development and integration of semantics resources into the biomedical research practice. The journal therefore aims at providing a forum for diss...

background: for xenograft models of triple-negative breast cancer (tnbc) to be valuable in development of molecularly-targeted drugs, careful characterization is essential to their validation. the present study aimed to validate the tnbc xenograft model with a specific focus on angiogenesis. methods : twelve tnbc xenograft tumors and 12 human breast cancer tumors (htnbc) were included in this s...