implied that the indications for surgery might be more important than surgery itself. There are several potential biases. Early symptoms in women with osteoarthritis may have been misinterpreted and resulted in hysterectomy. This is unlikely given the long median delay (six years) between operation and diagnosis and that those with spinal osteoarthritis did not have the greatest rate of hystere...

Abstract: Introduction: The purpose of the present study was to design, develop, and characterize transdermal patches containing Simvastatin for management blood lipid levels. Materials Methods: Transdermal were prepared by solvent casting method. evaluated physicochemical characteristics such as thickness, weight variation, folding endurance, percentage moisture uptake, content, drug ex-vivo p...

Background: Duloxetine hydrochloride is an antidepressant drug also approved for diabetic neuropathy, anxiety disorders, and fibromyalgia requiring repeated administration on chronic basis. The objective of this study was to develop a transdermal drug delivery system for duloxetine hydrochloride as a once daily dosage form. Methods: Transdermal patches were prepared by solvent evaporation metho...

Transdermal patches of carvedilol with a HPMC-drug reservoir were prepared by the solvent evaporation technique. In this investigation, the membranes of Eudragit RL100 and Eudragit RS100 were cast to achieve controlled release of the drug. The prepared patches possessed satisfactory physicochemical characteristics. Thickness, mass and drug content were uniform in prepared batches. Moisture vapo...

The objective of this study was to evaluate pharmacodynamical properties of transdermal therapeutic systems (TTS) containing captopril together with synthetic and pH independent polymers, Eudragit RL 100 and RS 100. Optimum formulation was chosen according to the results of our previous study regarding in vitro dissolution and ex vivo diffusion rate studies through excised human skin by using F...

Transdermal patches loaded with Solid Lipid Nanoparticles has been used as a suitable dosage to maintain the blood glucose level in diabetic patients. Repaglinide was taken as model antidiabetic drug get incorporated in Solid lipid Nanoparticles (SLNs) by a hot homogenization method using cephalin and lecithin as lipids and Tween 80 as stabilizer. The prepared nanoparticles evaluated for partic...

conclusions: although both pain killing therapeutic regimens are safe and effective for postoperative pain management, regarding the easy usage of the patches, lower risk of abuse and cost-effectiveness in the iranian market, it is recommended for use in iranian hospitals and trauma centers and in countries with similar socioeconomic situations. background: acute and severe pain is common in pa...

OBJECTIVE To describe a successful experience with a high dose (1000 microg/hr) of transdermal fentanyl for cancer pain relief. CASE REPORT A 62-year-old man suffering from rectal carcinoma was treated by our home care hospice unit during his last 3.5 months of life. At admission to our home care unit, he suffered mostly from severe anal pain (verbal pain scale of 10/10) due to advanced disea...

Transdermal drug delivery (TDD) is a non-invasive route of drug administration, although its applications are limited by low skin permeability. It is an attractive alternative technique over the conventional techniques for administration of systemic approaches. For both local and systemic effects skin is the major site of application. However, to penetrate the drug through skin, stratum corneum...

C mechanisms underlying (Rapid Eye Movement) REM sleep have been supported through different studies (1). In major depression, a hypersensitivity of the cholinergic system has been proposed (2). Cholinergic challenges have been used as a test for hypersensitivity of the cholinergic system in depressed patients and in the first degree relatives, looking for changes in sleep variables (3). Glassm...