Transdermal delivery is an attractive option for drug delivery. Nevertheless, the skin is a tough barrier and only a limited number of drugs can be delivered through it. The most difficult to deliver are hydrophilic drugs. The stinging mechanism of the cnidarians is a sophisticated injection system consisting of microcapsular nematocysts, which utilize built-in high osmotic pressures to inject ...

Conventional transdermal drug delivery systems (TDDS) have been designed for drug delivery through the skin. These systems use the permeability property of stratum corneum, the outermost surface layer of the skin. Applying polymeric micro and nanofibers in drug delivery has recently attracted great attention and the electrospinning technique is the preferred method for polymeric micro-nanofiber...

Transdermal Drug Delivery In article 2300066, Canan Dagdeviren and co-workers report a soft, conformable embodiment of wearable ultrasound patch for transdermal delivery cosmeceuticals to the skin. The comprises 2D array bulk piezoelectric transducers embedded in poly(dimethylsiloxane) substrate. demonstrates 26.2-fold enhancement niacinamide porcine skin vitro with 10 min application.

Transdermal drug delivery is the application of drug on the skin surface so that it can permeate through the skin and reaches the systemic circulation at sufficient concentration to ensure therapeutic efficacy. Transdermal drug delivery system (TDDS) has several advantages over conventional system; TDDS offers sustained drug release, avoidance of first pass effect, patient compliance, ease of a...

Transdermal drug delivery is a validated technology contributing significantly to global pharmaceutical care. Since 1980, impressive growth in this field has been observed with many commercial successes; importantly, a new chemical entity was recently developed and approved for transdermal administration without having first been given as an injectable or oral dosage form. The progress achieved...

Overview For thousands of years, human civilizations have applied substances to the skin as cosmetic and medicinal agents.(Prausnitz 2008) However, it was not until the twentieth century that the skin came to be used as a drug delivery route. In fact, Merriam Webster dates the word “transdermal” to 1944(Merriam-Webster 2011) highlighting that it is a relatively recent concept in medical and pha...

Transdermal administration of analgesic medications offers several benefits over alternative routes of administration, including a decreased systemic drug load with fewer side effects, and avoidance of drug degradation by the gastrointestinal tract. Transdermal administration also offers a convenient mode of drug administration over an extended period of time, particularly desirable in pain med...

Microemulsions have received great attention for applications in transdermal drug delivery. The use of curcumin for treating various skin diseases like scleroderma, psoriasis, and skin cancer was extensively reported. The solubility of curcumin in various oils, surfactants, and cosurfactants was studied herein in order to find the optimal components for a transdermal delivery vehicle. Microemul...

Purpose: Ofloxacin is a fluoroquinolone with broad-spectrum antibacterial action, used in treatment of systemic and local infections. Ofloxacin is BCS class II drug having low solubility, high permeability with short half-life. The present work was aimed to design, develop and optimize gellified emulsion of Ofloxacin to provide site targeted drug delivery. Transdermal drug delivery will enhance...