PURPOSE Weak direct currents induce lasting alterations of cortical excitability in animals and humans, which are controlled by polarity, duration of stimulation, and current strength applied. To evaluate its anticonvulsant potential, transcranial direct current stimulation (tDCS) was tested in a modified cortical ramp-stimulation model of focal epilepsy. METHODS The threshold for localized s...

Weak transcranial direct current stimulation (tDCS) induces persisting excitability changes in the human motor cortex. These plastic excitability changes are selectively controlled by the polarity, duration and current strength of stimulation. To reveal the underlying mechanisms of direct current (DC)-induced neuroplasticity, we combined tDCS of the motor cortex with the application of Na(+)-ch...

Transcranial direct current stimulation (TDCS) is an emerging technique of noninvasive brain stimulation that has been found useful in examining cortical function in healthy subjects and in facilitating treatments of various neurologic disorders. A better understanding of adaptive and maladaptive poststroke neuroplasticity and its modulation through noninvasive brain stimulation has opened up e...

Abstract Transcranial direct current stimulation (tDCS) of the primary motor cortex (M1) may have a beneficial effect on 24-hour retention learning in healthy older adults, but so far existing studies are small and inconclusive. In addition, it is suggested that conventional tDCS montage (CONV-tDCS) produce relatively non-focal compared to high-definition (HD-tDCS). At present, unclear whether ...

Transcranial direct current stimulation (tDCS) is a representative non-invasive brain stimulation method (NIBS). tDCS increases cortical excitability not only in healthy individuals, but also in stroke patients where it contributes to motor function improvement. Recently, two additional types of transcranial electrical stimulation (tES) methods have been introduced that may also prove beneficia...

Sleep disturbances are common across all age groups, and they encompass a broad range of impairments daytime functioning comorbid various clinical conditions. However, current treatment methods for sleep have several limitations. As the ‘top-down’ pathway is known to play an important role in sleep-wake regulation, as neuronal activity abnormalities been reported potential pathological mechanis...

Abstract Implicit motor sequence learning (IMSL) enables us to perform multiple single movements in a specific sequential order and is involved many of our daily activities (e.g., reaching, walking). Acquisition IMSL has been shown be significantly impaired Parkinson’s disease (PD). Research healthy individuals shows the potential for transcranial direct current stimulation (tDCS), non-invasive...

In this issue of the Journal, Brunoni and colleagues report on transcranial direct-current stimulation (tDCS) in the treatment of major depression.1 This technique, which delivers weak electrical direct current to the scalp to modulate brain function, is one of a growing number of noninvasive brain stimulation interventions that change brain function and offer an opportunity to study brain–beha...

Objective: Previous studies have reported dorsolateral prefrontal cortex (DLPFC) and posterior parietal (PPC) activation during the performance of spatial working memory (SWM), so we decided to investigate the comparison of Transcranial Direct current stimulation (tDCS) effect between these two areas. Methods: Fifty-four healthy right-handed students (27 female, 27 male; age= 24.3±.2 years) w...

Our capacity to share the experiences of others is a critical part of social behaviour. One process thought to be important for this is vicarious perception. Passively viewing touch activates some of the same network of brain regions as the direct experience of touch. This vicarious experience is usually implicit, but for some people, viewing touch evokes conscious tactile sensations (mirror-to...