(+)-Fastigiatine was assembled in six steps from (R)-5-methylcyclohex-2-en-1-one. Intermolecular Diels-Alder reaction introduced most of the carbon atoms for the target. The two Boc-protected nitrogen atom building blocks were introduced by a Suzuki coupling and a cuprate addition. A biomimetic transannular Mannich reaction generated the two quaternary centers at a late stage. Each step builds ...

We are indebted to the reviewers for their contribution to the science, and the interest they showed to our article. Criticisms of Dr Anderson have given the impression that we might not be able to elucidate our hypothesis very well, which suggested an aortic dextroposition ranging between 5% and 95%. Our relevant presentation ‘‘Dextroposition of aorta in tetralogy of Fallot’’, which was submit...

Cyclododecane preferentially adopts a square-like geometry, giving rise to corner and edge methylene (CH2) groups, whose hydrogens assume different orientations. In CH2 can be inward- (endo) outward-looking (exo) the ring. Herein, we have quantum-chemically studied replacement of two in cyclododecane with iodines at relative positions 1,4, 1,5, 1,6, 1,7. Intramolecular interactions are only sli...

The title compound, C(23)H(25)NSi, has an eight-membered silicon-containing heterocyclic ring with an intra-molecular N⋯Si close contact, the transannular distance of which is 2.6294 (18) Å. The resulting geometry about the Si atom is distorted trigonal-bypyramidal, with the N and H atoms occupying apical sites. The dihedral angle between the aromatic rings fused to the eight-membered ring is 6...

Methods The study is based on a group of 71 pediatric patients operated in Heart Institute between September, 2001 and July, 2006, surgically corrected per primam, without prior palliations. The surgical techniques were: transannular patch (46), infundibular patch (12), infundibular patch + pulmonary patch (5), transatrial + transpulmonary repair (8). The patients were divided into 2 groups, co...

In an endeavor directed towards the construction of the oxabicyclic[3.2.1]octane segment present in the bioactive natural products of cortistatins and icetexanes genre, the title compound, C(13)H(19)BrO(3), was synthesized from (4aR,9aS)-1,3,4,4a,5,6,9,9a-octa-hydro-spiro-[benzo[7]annulene-2,2'-[1,3]dioxolane]-4a-ol via a transannular bromo-etherification protocol. The six-membered ring adopts ...

Dipivaloylketene (2) is obtained by flash vacuum pyrolysis of furan-2,3-dione 6 and dimerizes to 1,3-dioxin-4-one 3, which is a stable but reactive ketene. The transannular addition and rearrangement of enols formed by the addition of nucleophiles to the ketene function in 3 generates axially chiral 2,6,9-trioxabicyclo[3.3.1]nonadienes (bisdioxines) 4. When arylamines are used as the nucleophil...

OBJECTIVE Junctional ectopic tachycardia is common after pediatric heart surgery. After tetralogy of Fallot repair, the incidence of junctional ectopic tachycardia may be as high as 15% to 20%. We introduced prophylactic amiodarone for tetralogy repair. This study was conducted to evaluate the effectiveness of the prophylactic amiodarone. METHODS A continuous infusion of amiodarone was starte...

Dibromination of [2.2]paracyclophane (I) led to predominantly pseudo-ortho2 (11) and pseudo-para2 (111) disubstituted compounds, and to lesser amounts of pseudo-meta (IV) and para (V) isomers. Oxidation of these dibromides gave terephthalic acids whose esters were identified by vpc, and whose structures allowed homoannular and transannular bromination to be differentiated. Tetrabromination of I...