نتایج جستجو برای: transamidation

تعداد نتایج: 189  

Arvind Tomar Ram Singh Ratnesh Das Yogendra Singh,

Densely functionalized 3-(4-chlorophenyl)-5-(3-hydroxy-4-etoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide was  synthesized in an expedient manner through specification and transamidation  respectively, of ester-functionalized pyrazoles. This synthetic protocol allowed for three diversifying steps in which appendages on the pyrazole scaffold were adjusted to optimize inhibition of protein kina...

Journal: :The Journal of biological chemistry 1966
A N Glazer

The hydrolysis of a series of esters of benzoyl-L-arginine and glycylglycine by papain has been examined in mixtures of water with various alcohols in the pH range of 5 to 6. The presence of straight chain alcohols resulted in an apparent inhibition of acid release. It was shown that this inhibition could, in part, be accounted for by papain-catalyzed transesterification reactions between the v...

Journal: :American journal of physiology. Cell physiology 2000
Y Hiroi R Chen H Sawa T Hosoda S Kudoh Y Kobayashi H Aburatani K Nagashima R Nagai Y Yazaki M E Medof I Komuro

Glycosyl phosphatidylinositols (GPIs) are used to anchor many proteins to the cell surface membrane and are utilized in all eukaryotic cells. GPI anchoring units are attached to proteins via a transamidase reaction mediated by a GPI transamidase complex. We isolated one of the components of this complex, mGPAA1 (murine GPI anchor attachment), by the signal sequence trap method. mGPAA1 cDNA is a...

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