نتایج جستجو برای: transamidation
تعداد نتایج: 189 فیلتر نتایج به سال:
Densely functionalized 3-(4-chlorophenyl)-5-(3-hydroxy-4-etoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide was synthesized in an expedient manner through specification and transamidation respectively, of ester-functionalized pyrazoles. This synthetic protocol allowed for three diversifying steps in which appendages on the pyrazole scaffold were adjusted to optimize inhibition of protein kina...
The hydrolysis of a series of esters of benzoyl-L-arginine and glycylglycine by papain has been examined in mixtures of water with various alcohols in the pH range of 5 to 6. The presence of straight chain alcohols resulted in an apparent inhibition of acid release. It was shown that this inhibition could, in part, be accounted for by papain-catalyzed transesterification reactions between the v...
Glycosyl phosphatidylinositols (GPIs) are used to anchor many proteins to the cell surface membrane and are utilized in all eukaryotic cells. GPI anchoring units are attached to proteins via a transamidase reaction mediated by a GPI transamidase complex. We isolated one of the components of this complex, mGPAA1 (murine GPI anchor attachment), by the signal sequence trap method. mGPAA1 cDNA is a...
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