Epithelial-mesenchymal transition (EMT) is associated with metastasis formation, generation and maintenance of cancer stem cells (CSCs). However, the regulatory mechanisms of CSCs have not been clarified. This study aims to investigate the role of TNF receptor-associated factor 6 (TRAF6) on EMT and CSC regulation in squamous cell carcinoma of head and neck (SCCHN). We found TRAF6 was overexpres...

مداخل يعسوت رامعم ميمصت " ةجاحلا بسح ةددعتم طئاسو " ABSTRACT in this paper we develop a Vhdlbased scalable architecture of a multimedia on demand server model. Te three server subsystems are:the control subsystem, the communication subsystem and the storage subsystem are modeled. The communication subsystem is designed as an interconnection network with meshed-pipe structure and delivers packe...

The aim of the present study was to investigate the clinical significance of TNF receptor-associated factor 6 (TRAF6) expression in urothelial bladder cancer. TRAF6 expression was detected by immunohistochemistry in 126 samples of patients with urothelial bladder cancer. The association between clinicopathological factors and TRAF6 expression was analyzed by χ2 test. The association between TRA...

1 يوجشناد سانشراک ی ،هیذغت مولع دشرا ،نارهت یکشزپ مولع هاگشناد ،یسانش میژر و هیذغت هدکشناد ناریا 2 لوئسم هدنسیون : هورگ رایداتسا هیذغت هعماج ،ناریا ،نارهت یکشزپ مولع هاگشناد ،یسانش میژر و هیذغت هدکشناد ، یکینورتکلا تسپ : [email protected] 3 داتسا هورگ هیذغت هعماج هدکشناد، هیذغت میژرو هاگشناد،ینامرد مولع یکشزپ ،نارهت ناریا 4 يارتکد تملاس تاقیقحت یلم وتیتسنا ،ناهفصا یتشادهب ت...

BACKGROUND Lupus nephritis (LN) is a major complication of systemic lupus erythematosus (SLE). This study tested miR-146a and its target gene TRAF6 expression in LN patients and discussed their relationship with LN. MATERIAL AND METHODS One hundred twenty-eight LN patients and 30 healthy controls were enrolled in this study. MiR-146a and TRAF6 expression in peripheral blood mononuclear cells (P...

The present study aims to investigate the effects of miR-146a on the proliferation and apoptosis of human osteoarthritis (OA) chondrocytes by targeting tumour necrosis factor receptor-associated factor 6 (TRAF6) through nuclear factor-κB (NF-κB) signalling pathway. Human normal and OA chondrocytes were selected and divided into the normal group, blank group, negative control (NC) group, miR-146...

p38 mitogen-activated protein kinase (MAPK) is an essential kinase involved in myogenic differentiation. Although many substrates of p38 MAPK have been identified, little is known about its upstream activators during myogenic differentiation. TRAF6 is known to function in cytokine signaling during inflammatory responses. However, not much is known about its role in myogenic differentiation and ...

Muscle atrophy can result from inactivity or unloading on one hand or the induction of a catabolic state on the other. Muscle-specific ring finger 1 (MuRF1), a member of the tripartite motif family of E3 ubiquitin ligases, is an essential mediator of multiple conditions inducing muscle atrophy. While most studies have focused on the role of MuRF1 in protein degradation, the protein may have oth...

هلاقم تاعلاطا هدیکچ لماک یشهوژپ هلاقم :تفایرد 23 دنفسا 1392 :شریذپ 15 تشهبیدرا 1393 :تیاس رد هئارا 19 رهم 1393 رد اب هلاقم نیا رد يور مسج لمح يارب ریسم بیقعت یقیبطت لرتنک ،مسج نتفرگ نیح رد مسج و تابر کی هجنپ نیب شزغل ناکما نتفرگ رظن کت تابر کی طسوت نیمز رارق یسررب دروم یتشگنا یسررب يارب یبسانم هنومن ،متسیس نیا .تسا هتفرگ شور ياه فلتخم لیلحت دننام یحارط لرتنک هدننک اه رد تابر متسیس ماسجا ...

Regulatory T cells (Tregs) maintain immune homeostasis by limiting inflammatory responses. TRAF6 plays a key role in the regulation of innate and adaptive immunity by mediating signals from various receptors including the T-cell receptor (TCR). T cell-specific deletion of TRAF6 has been shown to induce multiorgan inflammatory disease, but the role of TRAF6 in Tregs remains to be investigated. H...