Radiobiology experiments performed in space are deemed necessary for validation of risk-assessment methods. The understanding of space radiobiology experiments must combine knowledge of the space radiation environment, radiation transport, and models of biological response. The heavy ion transport code HZETRN has recently been combined with improved models of the galactic cosmic rays (GCR) and ...

Purpose: Lung cancer is the leading cause of cancer death with chance of survival restricted to a subset of NSCLC patients able to undergo surgical resection. However, the recurrence rate of NSCLC after surgery remains high with few prognostic indicators of clinical outcome. Prx1 is shown to be elevated in various cancers and confers an aggressive survival phenotype. We recently cloned the prx1...

A prerequisite for applying high-LET radiation like protons or carbon ions to patients is the precise knowledge of absorbed dose, specifically the depth dose distribution. The legal restraints imposed by the authorities requires the Bragg peak position to be reproduced within 0.5 mm and the calculated absorbed dose distribution to agree within 5% (on average) with the measurements. These condit...

Ion tracks, formed by the interaction of energetic charged particles with matter, have played an important role in the development of modern physics. More recently, MeV-GeV ion track production has been used to modify materials in a controlled manner [1,2], being a potential tool to engineer material properties in the nanometer to micrometer scale. MeV-GeV ions are finding recently wider use in...

An important problem in computational biology is predicting the structure of the large number of putative proteins discovered by genome sequencing projects. Fold-recognition methods attempt to solve the problem by relating the target proteins to known structures, searching for template proteins homologous to the target. Remote homologs that may have significant structural similarity are often n...

INTRODUCTION. Galactic cosmic rays (GCR) consisting of nuclei of all the known elements with kinetic energies extending from tens to millions of MeV pose a significant health hazard to future deep space operations. Even half of the radiation exposures expected in ISS will result from GCR components. The biological actions of these radiations are known to depend on the details of the energy depo...

The calculated dynamic behaviour of railway bridges during high-speed traffic differs from the actual its bearing structure. In case steel bridges, calculations often overestimate vibration responses and therefore lead to uneconomical results. This gap between calculation measurement constitutes a complex research issue, whereas consideration ballasted track in has major influence. Concerning d...

Car body acceleration is an important factor affecting track safety and ride comfort, which are two primary aspects of railway systems. Though track level is an important source of wagon body acceleration, no quantitative relation between them is available and the aim of this paper is to propose a method to address this issue. To do so, car body acceleration is determined using a 10 DOF simulat...

Audio and video data have become critical components of information systems and these systems need to e ciently manage the large storage requirements of this type of data. However, there are no formal data models for audio video data. In this paper, we present an algebraic formalism which attempts to provide the underpinnings for the design and implementation of systems which organize and query...