The development of the complex network of epithelial tubes that ultimately forms the Drosophila tracheal system relies on cell migration, cell shape changes, cell rearrangements, cell differentiation, and branch fusion . Most of these events are controlled by a combination of distinct transcription factors and cell-cell signaling molecules, but few proteins that do not fall within these two fun...

During development of tubular networks such as the mammalian vascular system, the kidney and the Drosophila tracheal system, epithelial tubes must fuse to each other to form a continuous network. Little is known of the cellular mechanisms or molecular control of epithelial tube fusion. We describe the cellular dynamics of a tracheal fusion event in Drosophila and identify a gene regulatory hier...

1. Pneumatikos IA, Dragoumanis CK, Bouros DE: Ventilator-associated pneumonia or endotracheal tube-associated pneumonia? An approach to the pathogenesis and preventive strategies emphasizing the importance of endotracheal tube. ANESTHESIOLOGY 2009; 110:673–80 2. Berra L, Curto F, Li Bassi G, Laquerriere P, Baccarelli A, Kolobow T: Antibacterial-coated tracheal tubes cleaned with the Mucus Shave...

Microbial biofilms has remained a major complication of tracheal intubation in patients requiring ventilator equipment. The aim of this study was to characterize bacterial and fungal biofilms in endotracheal tubes from intensive care unit (ICU) patients in Ahwaz, Iran. In this cross-sectional descriptive study, patients admitted to ICU that required mechanical ventilation for at least 24 hours ...

Oxygen delivery in many animals is enabled by the formation of unicellular capillary tubes that penetrate target tissues to facilitate gas exchange. We show that the tortuous outgrowth of tracheal unicellular branches towards their target tissues is controlled by complex local interactions with target cells. Slit, a phylogenetically conserved axonal guidance signal, is expressed in several trac...

background and objectives: nosocomial infections are one of the most important worldwide health and increased patients hospital stay, therapeutic problem and mortality rate. this study was designed to determine the frequency of microorganisms isolated from tracheal tube in patients admitted to icu shaheed mostafa khomeini hospital tehran, iran, from 2001-2005. patients and methods: in this cros...

Epithelial tubes that compose many organs are typically long lasting, except under specific developmental and physiological conditions when network remodeling occurs. Although there has been progress elucidating mechanisms of tube formation, little is known of the mechanisms that maintain tubes and destabilize them during network remodeling. Here, we describe Drosophila tendrils mutations that ...

Direct tracheoscopy was employed to assess tracheal damage following prolonged intubation. Comparison of conventional and low-pressure cuffs showed that there was less trauma from the low-pressure cuff. Comparison of tube sizes showed a reduction in injury with 8-mm diameter tubes compared with larger ones. Knowledge of tracheal damage following prolonged endotracheal intubation has depended hi...

BACKGROUND Branching morphogenesis transforms an epithelial sheet into a tubular network with distinct features regarding the length and diameter of individual tubes. Branching is controlled by several signaling pathways, but the molecular consequences of these pathways in the responding cells are poorly understood. RESULTS We have undertaken a detailed characterization of cell rearrangements...