Abstract Clinical trial endpoints include response/survival, but also treatment tolerance and clinical benefit. Few reports exist on the frequency type of disease-related symptoms functions treatment-associated symptomatic toxicities at initiation. The MD Anderson Symptom Inventory-Brain Tumor self-reports from patients baseline a initiation were retrospectively evaluated for presence severe ra...

PURPOSE Stereotactic body radiation therapy (SBRT) is increasingly utilized as primary treatment for clinically localized prostate cancer. While acute post-SBRT urinary symptoms are well recognized, the late genitourinary toxicity of SBRT has not been fully described. Here, we characterize the clinical features of late urinary symptom flare and recommend conservative symptom management approach...

Dear Editor, The access to medical care is unacceptably low worldwide in spite of the increasing demand for medical care due to population aging and increasing burden of non-infectious diseases...

The current mechanism for monitoring toxicity symptoms in cancer trials depends on a complex paper-based process. Electronic collection of patient-reported outcomes (PROs) may be more efficient and accurate. An online PRO platform was created including a simple data entry interface, real-time report generation, and an alert system to e-mail clinicians when patients self-report serious toxicitie...

Kratom, a relatively unknown herb among physicians in the western world, is advertised on the Internet as an alternative to opioid analgesics, as a potential treatment for oploid withdrawal and as a "legal high" with minimal addiction potential. This report describes a case of kratom addiction in a 37-year-old woman with a severe oploid-like withdrawal syndrome that was managed successfully wit...

The treatment options for unresectable stage III NSCLC include definitive RT, chemotherapy, combined chemoradiotherapy, or supportive care. Compared with radiation alone or chemotherapy alone, the combination of chemotherapy and standard RT confers a modest survival benefit at the cost of increased toxicity for patients with an excellent performance status. For metastatic disease, combination c...

Lhermitte's sign (LS) is a transient symptom consisting of an electric shock-like sensation radiating ascending along the spinal cord during forward flexion neck. It may be associated with sensory complaints such as hypo or hyperesthesia. Although it more common in cervical lesions, can also seen less frequently thoracic lesions. LS classified one paroxysmal pain syndromes multiple sclerosis (M...

To cite: Golomb BA, Koslik HJ, Redd AJ. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2015209821 SUMMARY We present a case series of four previously healthy, employed adults without significant prior medical history in each of whom symptoms developed while on fluoroquinolones (FQs), with progression that continued following discontinuation evolving to a severe, ...

Tianeptine is often incorrectly described as a selective serotonin reuptake inhibitor, but it actually µ-opioid receptor agonist with anxiolytic effects. It has been approved since the last 1980s in about 24 countries treatment for depression, was never cleared to market United States this purpose. Nevertheless, tianeptine joined billion-dollar US of nootropics ZaZa or Tianna Red and widely ava...