Hybrid molecules obtained through conjugation of monoclonal antibodies and toxins constitute an approach under exploration to generate potential agents for the treatment of cancer and other diseases. A frequently employed toxic component in the construction of such immunotoxins is ricin, a plant toxin which inhibits protein synthesis at ribosomal level and so requires to be internalized by the ...

Nowadays, microalgae are particularly used to assess the environmental impact of contaminants in aquatic systems. Naturally present in some algal species, bioluminescence is highly used in application fields related to environmental monitoring. Bioluminescent dinoflagellates have played a pivotal role in this domain. When exposed to heavy metals or toxic organic compounds, bioluminescent dinofl...

Introduction Many of the substances used as food additives possess no outstanding toxic property; others which may be used as adjuncts in processing may be toxic but are present in the food only in very small quantities. The study of non-toxic substances resolves itself into the problem of trying to prove a negative. An experimental investigation of the toxicity of many of the chemicals used in...

Titanium dioxide nanoparticles (TiO₂ NPs) are widely used in sunscreens, cosmetics and body implants, and this raises toxicity concerns. Although a large number of reports claim that they are safe to use, others claim that they induce reactive oxygen species formation and can be carcinogenic. In this study, the origins of toxic response to TiO₂ NPs were investigated by using Surface-enhanced Ra...

Introduction Many of the substances used as food additives possess no outstanding toxic property; others which may be used as adjuncts in processing may be toxic but are present in the food only in very small quantities. The study of non-toxic substances resolves itself into the problem of trying to prove a negative. An experimental investigation of the toxicity of many of the chemicals used in...

CONTEXT Toxic shock syndrome has been shown previously to be associated with hyperamylasaemia. However, serum amylase levels do not usually exceed three times upper limit of normal in these cases. CASE REPORT We report a case of a young girl of 17 years who presented with upper abdominal pain, severe shock and raised serum amylase level of 3,898 U/L, giving an impression of severe acute pancr...

Use of chemical criteria in assessing the potential for adverse toxic effects in contaminated sites can under or overestimate the necessary level of site cleanup required. The use of ecotoxicity testing provides a more direct assessment of adverse environmental impact. A multi-trophic level soil ecotoxicity assessment was done on soil contaminated with crude oil distilled into five different fr...

This study was undertaken to compare the electrolytes K, and Na levels serum of (67) toxic digitalis uremic heart failure patients their in 50 (not toxic) patients.
 The electrolyte level K found be very low severe hyponatremia hypokalemia while were near normal values or slightly higher patients. does not support that digoxin might have a protective effect against renal dysfunction

Cadmium concentrations in kidneys from ringed seals (Phoca hispida) from North West Greenland (Qaanaaq) are high. Concentrations range at level known to induce renal toxic effects (mainly tubulopathy) and demineralisation (osteopenia) of the skeletal system (Fanconi’s Syndrome) in humans as well as laboratory mammals. We have studied possible cadmium induced histopathological changes in the kid...

A prospective study to correlate clinical digoxin toxicity with serum digoxin levels was carried out in 67 patients of whom 24 were clinically toxic and 43 were asymptomatic. The patients were clinically diagnosed to be toxic based on typical cardiac arrhythmias (n = 11) or non-cardiac symptoms (n = 13). Blood samples were collected at least six hours after the last digoxin dose and the sera as...