While there has been much work on finding and developing top performers in the workplace, less attention has been focused on how to manage those workers who are harmful to organizational performance. In the most dramatic form, such workers can generate enormous regulatory and legal liabilities for the firm, harm its reputation, and invalidate its corporate social responsibility program. We expl...

747 1941-Lathyrus sativus peas, spastic paraparesis; the toxic agent was identified to be 1)-JY-methylamino-Lalanine (BMAA); 1953-Guamalian type of Parkinsonism, caused by the seeds of Cycas circinalis; the toxic agent was identified as 1)-JY-oxalylmethylamino-Lalanine (BOMAA); 1948-hexachloraphene encephalopathy; 1950-monosodium glutamate in baby food; 1953-Minamata disease, mercury encephalop...

Examples of toxic cardiomyopathies of various characteristics are presented. Daunomycin and doxorubicin, antineoplastic drugs, cause multifocal cardiomyopathies and intractable heart failure by cardiotoxic mechanisms; these effects are delayed and related to the cumulative dose. Cobalt caused diffuse vacuolar cardiomyopathy in chronic beer drinkers. The development of fulminant heart failure wa...

4-Hydroxyanisole (4-OHA) was administered to C57Bl/lOJ mice in which B16 melanoma or Lewis lung carcinoma had been implanted s.c. or i.m. The drug had the largest antitumour effect against B16 melanoma growing s.c. and a smaller antitumour effect against B16 melanoma or Lewis lung carcinoma growing i.m. In the treatment regimens where drug was administered only after tumour implantation, a sign...

history of excessive perspiration three months previously, followed two weeks later by a "sweat rash." She became very fretful, refused her food, and did not sleep. There was marked photophobia. She was admitted to hospital, and kept on sedatives to procure sleep. She took her feeds better, but began to have a temperature; loose motions followed, and eventually she died of gastro-enteritis. In ...

Introduction. Non-ferrous smelters are one of the critical nanoscale cadmium particles sources in workplace and ambient air. Materials methods. The research was performed to evaluate subchronic toxicity oxide nanoparticles (CdO-NPs) white outbred rats. Male 3.5-month old rats received intraperitoneal injections CdO-NPs 3 times a week for six weeks (18 total) doses 0.25 mg/kg body mass. After en...