healthy hire effect (hhe) is considered as an epidemiological phenomenon, complicating the assessment of a true cause - effect relationship between occupational exposure and health status of workers. the current study was aimed at identification and elimination of hhe in the risk assessment of arterial hypertension (ah) in coal miners. overall, 1553 miners, working in west siberia, were enrolle...

Although acute symptoms recurred during treatment in seven of the cases on aspirin, there was no evidence of recrudescence in the phenylbutazone group. REFERENCES Ablard, G., Larcan, A., and Welfringer, A. (1957). Un. m'd. Can., 86, 932. Begg, T. B., Kerr, J. W., and Knowles, B. R. (1962). Brit. med. 7., 2, 223. Chaptal, J., Jean, R., and Campo, C. (1956). Sem. Hop. Paris, 32, 1175. Colson, J. ...

background: the ob­jective of this study was to find an appropriate approach to asymptomatic malaria in elimination setting through a systematic review. methods: a broad search was conducted to find articles with the words ‘malaria’ in their titles and ‘asymptomatic’ or ‘submicroscopic’ in their texts, irrespective of the type of study conducted. the cochrane, medline/pubmed, and scopus databas...

Return on investment is a driving force that motivates and is a reward for investors. Investment returns are important for investors, in order for the entire investment game to be realized. Evaluating efficiency is the only logical way (Before risk assessment) that investors can do to compare alternative and different investments. Measuring real returns (relative to the past) is needed to bette...

The developmental changes in caffeine elimination were studied in 7 infants aged between 2 1/2 weeks and 6 months. Adult plasma clearance rate of caffeine was achieved at 3 to 4 1/2 months of age. Plasma half-life and elimination rate reached adult levels after 3 to 4 1/2 months and seemed to exceed adult capacity thereafter. No significant changes in apparent volume of distribution were noted....

The present study was carried out to investigate disposition kinetics of moxifloxacin following single-dose intravenous (i.v.), intramuscular (i.m.), and subcutaneous (s.c.) administration at a dose rate of 5 mg/kg of body weight (b.wt.) in goats. Plasma samples collected after treatments were analyzed for drug concentration using high-performance liquid chromatography (HPLC). After i.v. admini...

The aim of this study was an in vitro - in vivo evaluation of a new oral dosage form of tramadol hydrochloride (TH), controlled-release capsules filled with coated pellets, 100 mg (TC), compared to the sustained release tablets, Tramal Retard, 100 mg (TR). In vitro release study of both formulations showed a similar release profile of TH over 8 h (f2 was 52). In vivo study (single oral, 100 mg ...

The elimination pharmacokinetics of cefoperazone, a new cephalosporin, were studied in 15 preterm infants ranging in gestational age from 32 to 36 weeks and in postnatal age from 1 to 6 days. The infants received a single dose of either 50 or 250 mg of cefoperazone per kg by intravenous infusion. Blood samples were collected at specified times after completion of the drug infusion and then assa...

Faster elimination of drug tolerant 'persister' bacteria may shorten treatment of tuberculosis (TB) but no method exists to quantify persisters in clinical samples. We used automated image analysis to assess whether studying growth characteristics of individual Mycobacterium tuberculosis colonies from sputum on solid media during early TB treatment facilitates 'persister' phenotyping. As Time t...