Idiopathic CD4+ T-lymphocytopenia (ICL) is a new disease entity characterized by CD4+ T-lymphocyte depletion without evidence of HIV infection. We report a 27-year-old ICL patient with a long history of multiple immune abnormalities. His CD4+ T-lymphocyte count started to decrease after generalized lymphadenopathy of an unknown cause at age 3. He satisfied the criteria for ICL at age 9, and the...

A novel inductive logic programming system, called Classic’cl is presented. Classic’cl integrates several settings for learning, in particular learning from interpretations and learning from satisfiability. Within these settings, it addresses predictive, descriptive and probabilistic modeling tasks. As such, Classic’cl (C-armr, cLAudien, icl-S(S)at, ICl, and CLlpad) integrates several well-know...

Purpose: To investigate the causes of Implantable Collamer Lens (ICL) explantation and study the visual outcomes after further management in a retrospective case series. Methods: Retrospective chart review was performed for all the eyes that underwent bilateral or unilateral ICL explantation between March 2010 and April 2015. Incidence & causes of explantation, time between primary & secondary ...

The properties of the autonomically regulated chloride current (ICl) were studied in isolated guinea pig ventricular myocytes. This current was elicited upon exposure to isoproterenol (ISO) and reversed upon concurrent exposure to acetylcholine (ACh). ICl was time independent and exhibited outward rectification. The responses to ISO and ACh could be blocked by propranolol and atropine, respecti...

Fanconi anemia (FA) is a genetic disease characterized by bone marrow failure and increased cancer risk. The FA proteins function primarily in DNA interstrand crosslink (ICL) repair. Here, we have examined the role of the PTEN phosphatase in this process. We have established that PTEN-deficient cells, like FA cells, exhibit increased cytotoxicity, chromosome structural aberrations, and error-pr...

IFN-inducible CXCR3 ligands (ICL), namely CXCL9, CXCL10 and CXCL11, exhibit pleiotropic roles in orchestrating immunity and angiogenesis. However, the prognosis value of them in renal cell carcinoma (RCC) was still obscure. Thus, we retrospectively used immunohistochemistry approach to evaluate the impact of these ligands on recurrence and survival of non-metastatic clear cell RCC (ccRCC) patie...

Impaired DNA damage repair, especially deficient transcription-coupled nucleotide excision repair, leads to segmental progeroid syndromes in human patients as well as in rodent models. Furthermore, DNA double-strand break signalling has been pinpointed as a key inducer of cellular senescence. Several recent findings suggest that another DNA repair pathway, interstrand cross-link (ICL) repair, m...

Interstrand crosslink (ICL)-inducing agents block the separation of the two DNA strands. They prevent transcription and replication and are used in clinics for the treatment of cancer and skin diseases. Here, we have introduced a single psoralen ICL at a specific site in plasmid DNA using a triplex-forming-oligonucleotide (TFO)-psoralen conjugate and studied its repair in Xenopus egg extracts t...

In this research, the effects of a sedimentary basin, environmental conditions, and the passage of time were investigated on consolidation processes and engineering characteristics of fine-grained soils in Kerman city. For this purpose, the natural consolidation curves of soil samples extracted from different locations of Kerman city were compared with the Kerman city intrinsic consolidation li...

To the Editor: In their recent article, Reinstein et al.1 described the use of the Artemis 2 very high frequency digital ultrasound (ArcScan, Inc., Morrison, CO) to calculate the fit of the Visian Implantable Collamer Lens (ICL). Another parameter previously proposed as influencing ICL vaulting is the crystalline lens anterior radius of curvature (ALR).2 The ALR has not yet been used in any pre...