Local therapy for in-transit melanoma (ITM) is a treatment alternative for patients who are not good candidates for systemic therapy, regional therapy, or surgical management. In this case report, we describe 3 patients with ITM who were treated with intralesional Bacillus Calmette-Guérin (ILBCG) and/or topical imiquimod. Treatment course was dictated by the clinical response. Patient 1's respo...

Background: To evaluate the effect of an "escalation" topical glaucoma therapy by switching form prostaglandin mono to two different prostaglandin-timolol fixed combinations.

Background: Topical steroids have been advocated as an effective economical alternative to circumcision in boys with phimosis. This study was aimed at evaluating the effectiveness of topical steroid therapy as primary treatment of phimosis. Methods: Between December 2003 and February 2005, 182 of the 231 boys aged 14 years or younger who were referred to us with phimosis, were treated with a si...

Background and Aim: Since fluoride therapy is usually the first step of treatment in pediatric dentistry and it may interfere with other treatments, such as composite fill-ing, this study aimed to evaluate the possible effects of topical pre-fluoride therapy on marginal microleakage of composite restorations in deciduous teeth. Materials and Methods: In this in-vitro study, 30 deciduous canine...

Atopic dermatitis is a chronic inflammatory skin disease that affects large number of pediatric patients between 2 and 17 years age. Typical symptoms include intense itching, erythema, scaling the skin. has been found to be associated with decreased quality life for their families. Diagnosis made by clinical evaluation differential diagnosis other dermatologic diseases. Treatment based on sever...

BACKGROUND The diagnosis of atopic dermatitis (AD) is made using evaluated clinical criteria. Management of AD must consider the symptomatic variability of the disease. METHODS EADV eczema task force developed its guideline for atopic dermatitis diagnosis and treatment based on literature review and repeated consenting group discussions. RESULTS AND DISCUSSION Basic therapy relies on hydrat...

We present a 34-year-old female patient with methotrexate unresponsive longstanding plaque psoriasis who developed pustular psoriasis ten weeks after initiation of ustekinumab therapy. Given the lack of other side effects and the rapid initial response of the underlying plaque psoriasis, we opted against discontinuing ustekinumab therapy. Topical corticosteroids were added for the management of...

OBJECTIVES/HYPOTHESIS Topical steroid therapy is an important strategy in the management of chronic rhinosinusitis (CRS) with nasal polyposis. The objective of this study was to determine the impact of topical steroid therapy on nasal symptoms in patients with nasal polyposis. STUDY DESIGN Systematic review with meta-analysis using standardized methodology. METHODS Study inclusion criteria ...

Chronic plaque psoriasis, the most common form of psoriasis, is a papulosquamous disease defined by erythematous plaques with a silvery scale. The diagnosis usually is clinical, but occasionally a biopsy is necessary. Psoriasis affects 0.6 to 4.8 percent of the U.S. population, and about 30 percent of affected patients have a first-degree relative with the disease. Psoriasis is a T-cell-mediate...

PURPOSE To analyze the safety of warfarin therapy during cataract surgery under topical anesthesia. METHODS This was a prospective nonrandomized comparative study of 60 eyes of 60 patients treated with or without concurrent oral warfarin anticoagulant therapy, referred for cataract surgery under topical anesthesia. The sample included a treatment (n=30) and a control (n=30) group. RESULTS T...